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IL4I1 interleukin 4 induced 1 [ Homo sapiens (human) ]

Gene ID: 259307, updated on 4-Jun-2020

Summary

Official Symbol
IL4I1provided by HGNC
Official Full Name
interleukin 4 induced 1provided by HGNC
Primary source
HGNC:HGNC:19094
See related
Ensembl:ENSG00000104951 MIM:609742
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAO; FIG1; LAAO
Summary
This gene encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. The expression of this gene can be induced by interleukin 4 in B cells, however, expression of transcripts containing the first two exons of the upstream gene is found in other cell types. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Expression
Broad expression in testis (RPKM 12.4), liver (RPKM 8.9) and 22 other tissues See more
Orthologs

Genomic context

See IL4I1 in Genome Data Viewer
Location:
19q13.33
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49889654..49929504, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50392911..50432796, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene AKT1 substrate 1 Neighboring gene TBC1 domain family member 17 Neighboring gene microRNA 4750 Neighboring gene nucleoporin 62 Neighboring gene activating transcription factor 5 Neighboring gene microRNA 4751 Neighboring gene sialic acid binding Ig like lectin 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-amino-acid oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
polyamine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
L-phenylalanine catabolic process TAS
Traceable Author Statement
more info
 
cellular amino acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
lysosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
L-amino-acid oxidase
Names
Fig-1 protein
IL4-induced protein 1
interleukin four induced 1
NP_001244946.1
NP_001244947.1
NP_690863.1
NP_758962.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021170.1 RefSeqGene

    Range
    5002..44852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258017.2NP_001244946.1  L-amino-acid oxidase isoform 2 precursor

    See identical proteins and their annotated locations for NP_001244946.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. Variants 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC118342, DQ079589
    Consensus CDS
    CCDS12786.1
    UniProtKB/Swiss-Prot
    Q96RQ9
    Conserved Domains (2) summary
    pfam01593
    Location:91523
    Amino_oxidase; Flavin containing amine oxidoreductase
    pfam13450
    Location:86143
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  2. NM_001258018.2NP_001244947.1  L-amino-acid oxidase isoform 2 precursor

    See identical proteins and their annotated locations for NP_001244947.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. Variants 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC118342, DQ079588
    Consensus CDS
    CCDS12786.1
    UniProtKB/Swiss-Prot
    Q96RQ9
    Related
    ENSP00000472474.1, ENST00000595948.5
    Conserved Domains (2) summary
    pfam01593
    Location:91523
    Amino_oxidase; Flavin containing amine oxidoreductase
    pfam13450
    Location:86143
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  3. NM_152899.2NP_690863.1  L-amino-acid oxidase isoform 1 precursor

    See identical proteins and their annotated locations for NP_690863.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding region compared to variant 2. The resulting isoform (1) contains a distinct and shorter N-terminus, as compared to isoform 2. This transcript contains the first two exons of the upstream and is expressed from a different promoter.
    Source sequence(s)
    AF293462
    Consensus CDS
    CCDS12787.1
    UniProtKB/Swiss-Prot
    Q96RQ9
    Related
    ENSP00000375702.1, ENST00000391826.7
    Conserved Domains (2) summary
    pfam01593
    Location:69501
    Amino_oxidase; Flavin containing amine oxidoreductase
    pfam13450
    Location:64121
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  4. NM_172374.3NP_758962.1  L-amino-acid oxidase isoform 2 precursor

    See identical proteins and their annotated locations for NP_758962.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes a longer isoform (2). Variants 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC118342, DQ079587
    Consensus CDS
    CCDS12786.1
    UniProtKB/Swiss-Prot
    Q96RQ9
    Related
    ENSP00000342557.2, ENST00000341114.7
    Conserved Domains (2) summary
    pfam01593
    Location:91523
    Amino_oxidase; Flavin containing amine oxidoreductase
    pfam13450
    Location:86143
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RNA

  1. NR_047577.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011452, AC118342, AJ880389
    Related
    ENST00000601717.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49889654..49929504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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