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IL4I1 interleukin 4 induced 1 [ Homo sapiens (human) ]

Gene ID: 259307, updated on 9-Oct-2021

Summary

Official Symbol
IL4I1provided by HGNC
Official Full Name
interleukin 4 induced 1provided by HGNC
Primary source
HGNC:HGNC:19094
See related
Ensembl:ENSG00000104951 MIM:609742
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAO; FIG1; LAAO; hIL4I1
Summary
This gene encodes a secreted L-amino acid oxidase protein which primarily catabolizes L-phenylalanine and, to a lesser extent, L-arginine. The expression of this gene is induced by the cytokine interleukin 4 in B cells. This gene is also expressed in macrophages and dendritic cells. This protein may play a role immune system escape as it is expressed in tumor-associated macrophages and suppresses T-cell responses. This protein also contains domains thought to be involved in the binding of flavin adenine dinucleotide (FAD) cofactor. Multiple transcript variants encoding different isoforms have been found for this gene. Some transcripts of this gene share a promoter and exons of the 5' UTR with the overlapping NUP62 gene. [provided by RefSeq, Jul 2020]
Expression
Broad expression in testis (RPKM 12.4), liver (RPKM 8.9) and 22 other tissues See more
Orthologs
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Genomic context

See IL4I1 in Genome Data Viewer
Location:
19q13.33
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49889654..49929504, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50392911..50432761, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene AKT1 substrate 1 Neighboring gene TBC1 domain family member 17 Neighboring gene microRNA 4750 Neighboring gene nucleoporin 62 Neighboring gene activating transcription factor 5 Neighboring gene microRNA 4751 Neighboring gene sialic acid binding Ig like lectin 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-amino-acid oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-amino-acid oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-phenylalaine oxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables polyamine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
L-amino-acid oxidase
Names
Fig-1 protein
IL4-induced protein 1
interleukin four induced 1
NP_001244946.1
NP_001244947.1
NP_001372568.1
NP_690863.1
NP_758962.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021170.1 RefSeqGene

    Range
    5002..44852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258017.2NP_001244946.1  L-amino-acid oxidase isoform 2 precursor

    See identical proteins and their annotated locations for NP_001244946.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. The first two exons of its 5' UTR are shared with an upstream gene. Variants 2, 3 and 4 encode the same protein (isoform 2).
    Source sequence(s)
    AC118342, DQ079589
    Consensus CDS
    CCDS12786.1
    UniProtKB/Swiss-Prot
    Q96RQ9
    Conserved Domains (2) summary
    pfam01593
    Location:91523
    Amino_oxidase; Flavin containing amine oxidoreductase
    pfam13450
    Location:86143
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  2. NM_001258018.2NP_001244947.1  L-amino-acid oxidase isoform 2 precursor

    See identical proteins and their annotated locations for NP_001244947.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. The first two exons of its 5' UTR are shared with an upstream gene. Variants 2, 3 and 4 encode the same protein (isoform 2).
    Source sequence(s)
    AC118342, DQ079588
    Consensus CDS
    CCDS12786.1
    UniProtKB/Swiss-Prot
    Q96RQ9
    Related
    ENSP00000472474.1, ENST00000595948.5
    Conserved Domains (2) summary
    pfam01593
    Location:91523
    Amino_oxidase; Flavin containing amine oxidoreductase
    pfam13450
    Location:86143
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  3. NM_001385639.1NP_001372568.1  L-amino-acid oxidase isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding region, compared to variant 2, and is expressed from a different promoter. The resulting isoform (3) contains a distinct and shorter N-terminus, as compared to isoform 2.
    Source sequence(s)
    AC118342
    Conserved Domains (1) summary
    pfam01593
    Location:46464
    Amino_oxidase; Flavin containing amine oxidoreductase
  4. NM_152899.2NP_690863.1  L-amino-acid oxidase isoform 1 precursor

    See identical proteins and their annotated locations for NP_690863.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding region, compared to variant 2, and is expressed from a different promoter. The resulting isoform (1) contains a distinct and shorter N-terminus, as compared to isoform 2.
    Source sequence(s)
    AF293462
    Consensus CDS
    CCDS12787.1
    UniProtKB/Swiss-Prot
    Q96RQ9
    Related
    ENSP00000375702.1, ENST00000391826.7
    Conserved Domains (1) summary
    pfam01593
    Location:69501
    Amino_oxidase; Flavin containing amine oxidoreductase
  5. NM_172374.3NP_758962.1  L-amino-acid oxidase isoform 2 precursor

    See identical proteins and their annotated locations for NP_758962.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2). The first two exons of its 5' UTR are shared with an upstream gene. Variants 2, 3 and 4 encode the same protein (isoform 2).
    Source sequence(s)
    AC118342, DQ079587
    Consensus CDS
    CCDS12786.1
    UniProtKB/Swiss-Prot
    Q96RQ9
    Related
    ENSP00000342557.2, ENST00000341114.7
    Conserved Domains (2) summary
    pfam01593
    Location:91523
    Amino_oxidase; Flavin containing amine oxidoreductase
    pfam13450
    Location:86143
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RNA

  1. NR_047577.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon, compared to variant 2. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011452, AC118342, AJ880389
    Related
    ENST00000601717.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49889654..49929504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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