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TAS2R50 taste 2 receptor member 50 [ Homo sapiens (human) ]

Gene ID: 259296, updated on 22-Sep-2022

Summary

Official Symbol
TAS2R50provided by HGNC
Official Full Name
taste 2 receptor member 50provided by HGNC
Primary source
HGNC:HGNC:18882
See related
Ensembl:ENSG00000212126 MIM:609627; AllianceGenome:HGNC:18882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T2R50; T2R51; TAS2R51
Summary
TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). See also TAS2R10 (MIM 604791).[supplied by OMIM, Mar 2008]
Orthologs
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Genomic context

See TAS2R50 in Genome Data Viewer
Location:
12p13.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10985913..10986912, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10858932..10859931, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (11138512..11139511, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene PRH1-PRR4 readthrough Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene PRH1-TAS2R14 readthrough Neighboring gene taste 2 receptor member 14 Neighboring gene taste 2 receptor member 15 pseudogene Neighboring gene taste 2 receptor member 20 Neighboring gene taste 2 receptor member 19

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138305

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables bitter taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables bitter taste receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
taste receptor type 2 member 50
Names
taste receptor type 2 member 51
taste receptor, type 2, member 50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176890.2NP_795371.2  taste receptor type 2 member 50

    See identical proteins and their annotated locations for NP_795371.2

    Status: VALIDATED

    Source sequence(s)
    BC112100
    Consensus CDS
    CCDS8638.1
    UniProtKB/Swiss-Prot
    P59544, Q645Y0
    Related
    ENSP00000424040.1, ENST00000506868.1
    Conserved Domains (1) summary
    cd15027
    Location:3294
    7tm_TAS2R43-like; mammalian taste receptor 2, subtype 43, and related proteins, member of the seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    10985913..10986912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571050.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    184619..185618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    184606..185605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    10858932..10859931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)