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TAS2R46 taste 2 receptor member 46 [ Homo sapiens (human) ]

Gene ID: 259292, updated on 17-Jun-2024

Summary

Official Symbol
TAS2R46provided by HGNC
Official Full Name
taste 2 receptor member 46provided by HGNC
Primary source
HGNC:HGNC:18877
See related
Ensembl:ENSG00000226761 MIM:612774; AllianceGenome:HGNC:18877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T2R46; T2R54
Summary
TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Sep 2009]
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Genomic context

See TAS2R46 in Genome Data Viewer
Location:
12p13.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (11061365..11062294, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10936559..10937488, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (11213964..11214893, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene PRH1-PRR4 readthrough Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene PRH1-TAS2R14 readthrough Neighboring gene taste 2 receptor member 31 Neighboring gene taste 2 receptor member 63 pseudogene Neighboring gene MPRA-validated peak1573 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:11223850-11224544 Neighboring gene taste 2 receptor member 64 pseudogene Neighboring gene taste 2 receptor member 43

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics.
EBI GWAS Catalog

Pathways from PubChem

General protein information

Preferred Names
taste receptor type 2 member 46
Names
taste receptor type 2 member 54
taste receptor, type 2, member 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426846.1NP_001413775.1  taste receptor type 2 member 46 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents an alternate 'A' allele of the SNP rs2708381, which results in a premature stop codon in T2T-CHM13 genome assembly. The resulting protein lacks one transmembrane domain, and is shorter than isoform 1.
    Source sequence(s)
    CP068266
    UniProtKB/TrEMBL
    A0A0J9YY42, Q50KH1
  2. NM_176887.2NP_795368.2  taste receptor type 2 member 46 isoform 1

    See identical proteins and their annotated locations for NP_795368.2

    Status: VALIDATED

    Source sequence(s)
    AC018630
    Consensus CDS
    CCDS53748.1
    UniProtKB/Swiss-Prot
    P59540, P59548, Q645X6
    UniProtKB/TrEMBL
    Q50KH0
    Related
    ENSP00000436450.1, ENST00000533467.1
    Conserved Domains (1) summary
    pfam05296
    Location:1298
    TAS2R; Taste receptor protein (TAS2R)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    11061365..11062294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571050.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    260071..261000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    262229..263158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    10936559..10937488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)