U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TAS2R46 taste 2 receptor member 46 [ Homo sapiens (human) ]

Gene ID: 259292, updated on 13-May-2022

Summary

Official Symbol
TAS2R46provided by HGNC
Official Full Name
taste 2 receptor member 46provided by HGNC
Primary source
HGNC:HGNC:18877
See related
Ensembl:ENSG00000226761 MIM:612774; AllianceGenome:HGNC:18877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T2R46; T2R54
Summary
TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Sep 2009]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TAS2R46 in Genome Data Viewer
Location:
12p13.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (11061365..11062294, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10936559..10937488, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (11213964..11214893, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene PRH1-PRR4 readthrough Neighboring gene proline rich protein HaeIII subfamily 1 Neighboring gene PRH1-TAS2R14 readthrough Neighboring gene taste 2 receptor member 31 Neighboring gene taste 2 receptor member 63 pseudogene Neighboring gene taste 2 receptor member 64 pseudogene Neighboring gene taste 2 receptor member 43

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics.
EBI GWAS Catalog

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC134865

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables bitter taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables bitter taste receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in ciliary membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
taste receptor type 2 member 46
Names
taste receptor type 2 member 54
taste receptor, type 2, member 46

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176887.2NP_795368.2  taste receptor type 2 member 46

    See identical proteins and their annotated locations for NP_795368.2

    Status: VALIDATED

    Source sequence(s)
    AC018630
    Consensus CDS
    CCDS53748.1
    UniProtKB/Swiss-Prot
    P59540
    Related
    ENSP00000436450.1, ENST00000533467.1
    Conserved Domains (1) summary
    pfam05296
    Location:1298
    TAS2R; Taste receptor protein (TAS2R)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    11061365..11062294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571050.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    260071..261000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187658.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    262229..263158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    10936559..10937488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)