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TAS2R40 taste 2 receptor member 40 [ Homo sapiens (human) ]

Gene ID: 259286, updated on 22-Sep-2022

Summary

Official Symbol
TAS2R40provided by HGNC
Official Full Name
taste 2 receptor member 40provided by HGNC
Primary source
HGNC:HGNC:18885
See related
Ensembl:ENSG00000221937 MIM:613964; AllianceGenome:HGNC:18885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR60; T2R40; T2R58
Summary
This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. A decrease in the expression of this gene is associated with hypogeusia. [provided by RefSeq, Jul 2017]
Orthologs
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Genomic context

See TAS2R40 in Genome Data Viewer
Location:
7q34
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (143222037..143223079)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (144577457..144578499)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (142919130..142920172)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene taste 2 receptor member 39 Neighboring gene uncharacterized LOC124901764 Neighboring gene uncharacterized LOC105375546 Neighboring gene TMEM139 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7901 Neighboring gene glutathione S-transferase kappa 1

Genomic regions, transcripts, and products

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of taste receptor, type 2, member 40 (TAS2R40) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC126844, MGC126846

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables bitter taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables bitter taste receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
taste receptor type 2 member 40
Names
G-protein coupled receptor 60
taste receptor type 2 member 58
taste receptor, type 2, member 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176882.2NP_795363.1  taste receptor type 2 member 40

    See identical proteins and their annotated locations for NP_795363.1

    Status: REVIEWED

    Source sequence(s)
    BC101795
    Consensus CDS
    CCDS43662.1
    UniProtKB/Swiss-Prot
    P59535, Q645W6
    Related
    ENSP00000386210.3, ENST00000408947.4
    Conserved Domains (1) summary
    cd15014
    Location:19308
    7tm_TAS2R40; mammalian taste receptor 2, subtype 40, member of the seven-transmembraneG-protein coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    143222037..143223079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    144577457..144578499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)