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SOSTDC1 sclerostin domain containing 1 [ Homo sapiens (human) ]

Gene ID: 25928, updated on 7-Apr-2025

Summary

Official Symbol
SOSTDC1provided by HGNC
Official Full Name
sclerostin domain containing 1provided by HGNC
Primary source
HGNC:HGNC:21748
See related
Ensembl:ENSG00000171243 MIM:609675; AllianceGenome:HGNC:21748
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAND7; USAG1; CDA019; ECTODIN
Summary
This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lung (RPKM 31.5), stomach (RPKM 24.1) and 9 other tissues See more
Orthologs
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Genomic context

See SOSTDC1 in Genome Data Viewer
Location:
7p21.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (16461481..16465738, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (16591217..16595471, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (16501106..16505363, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CDP-L-ribitol pyrophosphorylase A Neighboring gene NANOG hESC enhancer GRCh37_chr7:16254865-16255366 Neighboring gene ribosomal protein L36a pseudogene 29 Neighboring gene CRPPA antisense RNA 1 Neighboring gene MPRA-validated peak6411 silencer Neighboring gene uncharacterized LOC105375168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17982 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:16541518-16542018 Neighboring gene NANOG hESC enhancer GRCh37_chr7:16551577-16552078 Neighboring gene leucine rich repeat containing 72 Neighboring gene ataxin 2 like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association of lipid-lowering response to statins in combined study populations.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CRPPA

Clone Names

  • DKFZp564D206

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables BMP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables BMP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables BMP receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of epithelial cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mammary gland bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of determination of dorsal identity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pattern specification process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sclerostin domain-containing protein 1
Names
cystine-knot containing secreted protein
ectodermal BMP inhibitor
uterine sensitization-associated protein-1
wise

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015464.3NP_056279.1  sclerostin domain-containing protein 1 precursor

    See identical proteins and their annotated locations for NP_056279.1

    Status: REVIEWED

    Source sequence(s)
    AF361494, AI540640, AI927000
    Consensus CDS
    CCDS5360.1
    UniProtKB/Swiss-Prot
    A8MUA6, Q6X4U4, Q96HJ7, Q9Y3U3
    UniProtKB/TrEMBL
    A4D125
    Related
    ENSP00000304930.4, ENST00000307068.5
    Conserved Domains (1) summary
    pfam05463
    Location:6206
    Sclerostin; Sclerostin (SOST)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    16461481..16465738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    16591217..16595471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)