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SOSTDC1 sclerostin domain containing 1 [ Homo sapiens (human) ]

Gene ID: 25928, updated on 2-Aug-2020

Summary

Official Symbol
SOSTDC1provided by HGNC
Official Full Name
sclerostin domain containing 1provided by HGNC
Primary source
HGNC:HGNC:21748
See related
Ensembl:ENSG00000171243 MIM:609675
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAND7; USAG1; CDA019; ECTODIN
Summary
This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lung (RPKM 31.5), stomach (RPKM 24.1) and 9 other tissues See more
Orthologs

Genomic context

See SOSTDC1 in Genome Data Viewer
Location:
7p21.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (16461481..16465738, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (16501106..16505562, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CDP-L-ribitol pyrophosphorylase A Neighboring gene ribosomal protein L36a pseudogene 29 Neighboring gene CRPPA antisense RNA 1 Neighboring gene uncharacterized LOC105375168 Neighboring gene leucine rich repeat containing 72 Neighboring gene ataxin 2 like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association of lipid-lowering response to statins in combined study populations.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CRPPA

Homology

Clone Names

  • DKFZp564D206

Gene Ontology Provided by GOA

Function Evidence Code Pubs
BMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
BMP binding IDA
Inferred from Direct Assay
more info
PubMed 
BMP receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
mammary gland bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
negative regulation of determination of dorsal identity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
pattern specification process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sclerostin domain-containing protein 1
Names
cystine-knot containing secreted protein
ectodermal BMP inhibitor
uterine sensitization-associated protein-1
wise

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015464.3NP_056279.1  sclerostin domain-containing protein 1 precursor

    See identical proteins and their annotated locations for NP_056279.1

    Status: REVIEWED

    Source sequence(s)
    AF361494, AI540640, AI927000
    Consensus CDS
    CCDS5360.1
    UniProtKB/Swiss-Prot
    Q6X4U4
    UniProtKB/TrEMBL
    A4D125
    Related
    ENSP00000304930.4, ENST00000307068.5
    Conserved Domains (1) summary
    pfam05463
    Location:6206
    Sclerostin; Sclerostin (SOST)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    16461481..16465738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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