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Klk8 kallikrein related-peptidase 8 [ Mus musculus (house mouse) ]

Gene ID: 259277, updated on 8-Dec-2022

Summary

Official Symbol
Klk8provided by MGI
Official Full Name
kallikrein related-peptidase 8provided by MGI
Primary source
MGI:MGI:1343327
See related
Ensembl:ENSMUSG00000064023 AllianceGenome:MGI:1343327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NP; BSP1; Nrpn; Prss19
Summary
This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein exhibit impaired long-term potentiation and increased anxiety, as well as a hyperkeratosis phenotype. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]
Expression
Broad expression in stomach adult (RPKM 16.0), thymus adult (RPKM 5.0) and 17 other tissues See more
Orthologs
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Genomic context

See Klk8 in Genome Data Viewer
Location:
7 B3; 7 28.26 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43447001..43453250)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43797532..43803826)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene kallikrein related-peptidase 10 Neighboring gene kallikrein related-peptidase 9 Neighboring gene kallikrein related-peptidase 7 (chymotryptic, stratum corneum) Neighboring gene kallikrein related-peptidase 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in memory IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron projection morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
part_of serine protease inhibitor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kallikrein-8
Names
Brain Serine protease 1
protease, serine, 19 (neuropsin)
NP_001311327.1
NP_032966.1
XP_030098463.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324398.1NP_001311327.1  kallikrein-8 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AB074296, AC151989, EH106421
    Consensus CDS
    CCDS21182.1
    UniProtKB/Swiss-Prot
    Q61955, Q8K5D7
    UniProtKB/TrEMBL
    A0A0B6VRH9, A0A8C6I0D9
    Related
    ENSMUSP00000145580.2, ENSMUST00000205537.2
    Conserved Domains (1) summary
    smart00020
    Location:32252
    Tryp_SPc; Trypsin-like serine protease
  2. NM_008940.3NP_032966.1  kallikrein-8 preproprotein

    See identical proteins and their annotated locations for NP_032966.1

    Status: REVIEWED

    Source sequence(s)
    AB074296, AC151989, EH106421
    Consensus CDS
    CCDS21182.1
    UniProtKB/Swiss-Prot
    Q61955, Q8K5D7
    UniProtKB/TrEMBL
    A0A0B6VRH9, A0A8C6I0D9
    Related
    ENSMUSP00000082588.3, ENSMUST00000085461.4
    Conserved Domains (1) summary
    smart00020
    Location:32252
    Tryp_SPc; Trypsin-like serine protease

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43447001..43453250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242603.2XP_030098463.1  kallikrein-8 isoform X1

    Conserved Domains (1) summary
    smart00020
    Location:1131
    Tryp_SPc; Trypsin-like serine protease