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Nmt1 N-myristoyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 259274, updated on 12-Jan-2022

Summary

Symbol
Nmt1provided by RGD
Full Name
N-myristoyltransferase 1provided by RGD
Primary source
RGD:628642
See related
Ensembl:ENSRNOG00000002989
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables myristoyltransferase activity. Predicted to be involved in N-terminal peptidyl-glycine N-myristoylation and cellular ketone metabolic process. Predicted to act upstream of or within N-terminal protein myristoylation and in utero embryonic development. Predicted to be located in cytosol and plasma membrane. Predicted to be extrinsic component of membrane. Predicted to be active in cytoplasm. Orthologous to human NMT1 (N-myristoyltransferase 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Heart (RPKM 312.3), Thymus (RPKM 249.3) and 9 other tissues See more
Orthologs
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Genomic context

See Nmt1 in Genome Data Viewer
Location:
10q32.1
Exon count:
14
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87988826..88025405)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (91126689..91160721)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L22-like 1 pseudogene Neighboring gene complement C1q like 1 Neighboring gene dephospho-CoA kinase domain containing Neighboring gene phospholipase C, delta 3 Neighboring gene acyl-CoA binding domain containing 4 Neighboring gene HEXIM P-TEFb complex subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glycylpeptide N-tetradecanoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glycylpeptide N-tetradecanoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycylpeptide N-tetradecanoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables myristoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables myristoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in N-terminal peptidyl-glycine N-myristoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in N-terminal peptidyl-glycine N-myristoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in N-terminal peptidyl-glycine N-myristoylation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within N-terminal protein myristoylation ISO
Inferred from Sequence Orthology
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in cellular ketone metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glycylpeptide N-tetradecanoyltransferase 1
Names
NMT 1
myristoyl-CoA:protein N-myristoyltransferase 1
peptide N-myristoyltransferase 1
type I N-myristoyltransferase
NP_683689.1
XP_038941229.1
XP_038941230.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148891.2NP_683689.1  glycylpeptide N-tetradecanoyltransferase 1

    See identical proteins and their annotated locations for NP_683689.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097277
    UniProtKB/Swiss-Prot
    Q8K1Q0
    Related
    ENSRNOP00000004046.5, ENSRNOT00000004046.7
    Conserved Domains (3) summary
    COG5092
    Location:86484
    NMT1; N-myristoyl transferase [Lipid metabolism]
    pfam01233
    Location:137291
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:308483
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    87988826..88025405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085301.1XP_038941229.1  glycylpeptide N-tetradecanoyltransferase 1 isoform X1

    Conserved Domains (1) summary
    COG5092
    Location:16414
    NMT1; N-myristoyl transferase [Lipid metabolism]
  2. XM_039085302.1XP_038941230.1  glycylpeptide N-tetradecanoyltransferase 1 isoform X2

    Conserved Domains (2) summary
    pfam01233
    Location:1105
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:122308
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
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