U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Msi1 musashi RNA-binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 259272, updated on 23-Jul-2026
Official Symbol
Msi1provided by RGD
Official Full Name
musashi RNA-binding protein 1provided by RGD
Primary source
RGD:628778
See related
Ensembl:ENSRNOG00000001156 AllianceGenome:RGD:628778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Msi1h
Summary
Predicted to enable RNA binding activity; molecular condensate scaffold activity; and protein homodimerization activity. Involved in epithelial cell differentiation and response to hormone. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Biomarker of brain infarction and brain ischemia. Orthologous to human MSI1 (musashi RNA binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Testes (RPKM 48.8), Adrenal (RPKM 47.2) and 4 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Msi1 in Genome Data Viewer
Location:
12q16
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (46815225..46911852, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41158301..41251134, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene RNA, U4 small nuclear 1 Neighboring gene sirtuin 4 Neighboring gene phospholipase A2 group IB Neighboring gene uncharacterized LOC134481302 Neighboring gene uncharacterized LOC102547958 Neighboring gene transmembrane protein 258, pseudogene 2 Neighboring gene cytochrome c oxidase subunit 6A1 Neighboring gene TP53 regulated inhibitor of apoptosis 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Neurogenesis by progenitor cells in the ischemic adult rat hippocampus. Yagita Y, et al. Stroke, 2001 Aug. PMID 11486122
  2. RNA binding protein Musashi1 is expressed in sertoli cells in the rat testis from fetal life to adulthood. Saunders PT, et al. Biol Reprod, 2002 Feb. PMID 11804968
  3. Proliferation and differentiation of neural stem cells in adult rats after cerebral infarction. Zhang B, et al. Chin Med Sci J, 2004 Jun. PMID 15250238
  4. Differentiation of rat bone marrow cells cultured on artificial basement membrane containing extracellular matrix into a liver cell lineage. Okumoto K, et al. J Hepatol, 2005 Jul. PMID 15893847
  5. [Neural stem cell marker MSI-1 expression in rat telencephalon]. Kirik OV, et al. Morfologiia, 2011. PMID 21866813

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone.
    Title: Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone.
  2. Expression of Musashi-1 Increases in Bone Healing.
    Title: Expression of Musashi-1 Increases in Bone Healing.
  3. data suggest that in response to environmental cues that oppose cell cycle progression, regulation of Musashi function is required to promote target mRNA translation and cell fate transition
    Title: Neural stem and progenitor cell fate transition requires regulation of Musashi1 function.
  4. Results do not support MSI-1 as a putative neoplastic stem cell marker in colonic tumors co-expressing nuclear beta-catenin.
    Title: Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear β-catenin.
  5. Nestin and Musashi1 as the markers of neural stem cells in rat telencephalon following transitory focal ischemia
    Title: [Nestin and Musashi1 as the markers of neural stem cells in rat telencephalon following transitory focal ischemia].
  6. neuronal progenitor cells in the SGZ expressed Msi1 but not nestin.
    Title: Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular condensate scaffold activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(U) RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(U) RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to hormone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm EXP
Inferred from Experiment
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus EXP
Inferred from Experiment
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
RNA-binding protein Musashi homolog 1
Names
Musashi homolog 1(Drosophila)
musashi-1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148890.2 → NP_683688.1  RNA-binding protein Musashi homolog 1

    See identical proteins and their annotated locations for NP_683688.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q8K3P4
    UniProtKB/TrEMBL
    F1LRH1
    Related
    ENSRNOP00000001532.6, ENSRNOT00000001532.8
    Conserved Domains (3) summary
    TIGR01628
    Location:32 → 339
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110 → 183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:21 → 96
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    46815225..46911852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271088.1 → XP_063127158.1  RNA-binding protein Musashi homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8K3P4
    UniProtKB/TrEMBL
    F1LRH1

  2. XM_039089125.2 → XP_038945053.1  RNA-binding protein Musashi homolog 1 isoform X7

    UniProtKB/TrEMBL
    F1LRH1
    Conserved Domains (2) summary
    TIGR01628
    Location:8 → 236
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:7 → 80
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

  3. XM_039089122.2 → XP_038945050.1  RNA-binding protein Musashi homolog 1 isoform X4

    UniProtKB/TrEMBL
    F1LRH1
    Conserved Domains (3) summary
    TIGR01628
    Location:32 → 329
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110 → 183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:21 → 96
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

  4. XM_039089121.2 → XP_038945049.1  RNA-binding protein Musashi homolog 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GAA4, F1LRH1
    Related
    ENSRNOP00000084373.1, ENSRNOT00000117406.3
    Conserved Domains (3) summary
    TIGR01628
    Location:32 → 320
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110 → 183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:21 → 96
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

  5. XM_039089120.2 → XP_038945048.1  RNA-binding protein Musashi homolog 1 isoform X2

    UniProtKB/TrEMBL
    F1LRH1
    Conserved Domains (3) summary
    TIGR01628
    Location:32 → 328
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110 → 183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:21 → 96
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

  6. XM_039089123.2 → XP_038945051.1  RNA-binding protein Musashi homolog 1 isoform X5

    UniProtKB/TrEMBL
    F1LRH1
    Conserved Domains (2) summary
    TIGR01628
    Location:54 → 295
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:66 → 139
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

  7. XM_063271091.1 → XP_063127161.1  RNA-binding protein Musashi homolog 1 isoform X9

  8. XM_063271090.1 → XP_063127160.1  RNA-binding protein Musashi homolog 1 isoform X8

  9. XM_039089124.2 → XP_038945052.1  RNA-binding protein Musashi homolog 1 isoform X6

    Conserved Domains (2) summary
    TIGR01628
    Location:37 → 241
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:36 → 85
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_010056364.1 RNA Sequence

  2. XR_010056363.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3P4.1 GenPept UniProtKB/Swiss-Prot:Q8K3P4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools