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CNRIP1 cannabinoid receptor interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 25927, updated on 7-Apr-2024

Summary

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Official Symbol
CNRIP1provided by HGNC
Official Full Name
cannabinoid receptor interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:24546
See related
Ensembl:ENSG00000119865 MIM:618538; AllianceGenome:HGNC:24546
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRIP1; CRIP-1; C2orf32
Summary
This gene encodes a protein that interacts with the C-terminal tail of cannabinoid receptor 1. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]
Expression
Broad expression in brain (RPKM 31.7), ovary (RPKM 14.7) and 21 other tissues See more
Orthologs
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Genomic context

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See CNRIP1 in Genome Data Viewer
Location:
2p14
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (68284171..68319949, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (68294742..68330519, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (68511303..68547081, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15947 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59016 Neighboring gene partner of NOB1 homolog Neighboring gene VISTA enhancer hs2040 Neighboring gene protein phosphatase 3 regulatory subunit B, alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:68432700-68433200 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59162 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59182 Neighboring gene uncharacterized LOC107985892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11587 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11588 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:68480114-68480783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11589 Neighboring gene Sharpr-MPRA regulatory region 10638 Neighboring gene uncharacterized LOC102724389 Neighboring gene CRISPRi-validated cis-regulatory element chr2.2452 Neighboring gene uncharacterized LOC101927723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15949 Neighboring gene pleckstrin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease. Oliver EE, et al. Biomolecules, 2020 Nov 27. PMID 33261012, Free PMC Article
  2. Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery? Smith TH, et al. Br J Pharmacol, 2010 Jun. PMID 20590557, Free PMC Article
  3. DNA Methylation of Cannabinoid Receptor Interacting Protein 1 Promotes Pathogenesis of Intrahepatic Cholangiocarcinoma Through Suppressing Parkin-Dependent Pyruvate Kinase M2 Ubiquitination. Chen D, et al. Hepatology, 2021 May. PMID 32955740
  4. Tat-Cannabinoid Receptor Interacting Protein Reduces Ischemia-Induced Neuronal Damage and Its Possible Relationship with 14-3-3η. Kwon HJ, et al. Cells, 2020 Aug 3. PMID 32756411, Free PMC Article
  5. Cannabinoid Receptor Interacting Protein 1a (CRIP1a): Function and Structure. Booth WT, et al. Molecules, 2019 Oct 12. PMID 31614728, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deciphering the Molecular Association of Human CRIP1a with an Agonist-Bound Cannabinoid Receptor 1.
    Title: Deciphering the Molecular Association of Human CRIP1a with an Agonist-Bound Cannabinoid Receptor 1.
  2. DNA Methylation of Cannabinoid Receptor Interacting Protein 1 Promotes Pathogenesis of Intrahepatic Cholangiocarcinoma Through Suppressing Parkin-Dependent Pyruvate Kinase M2 Ubiquitination.
    Title: DNA Methylation of Cannabinoid Receptor Interacting Protein 1 Promotes Pathogenesis of Intrahepatic Cholangiocarcinoma Through Suppressing Parkin-Dependent Pyruvate Kinase M2 Ubiquitination.
  3. Cannabinoid Receptor Type 1 Regulates Drug Reward Behavior via Glutamate Decarboxylase 67 Transcription.
    Title: Cannabinoid Receptor Type 1 Regulates Drug Reward Behavior via Glutamate Decarboxylase 67 Transcription.
  4. Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease.
    Title: Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease.
  5. A rare genomic duplication in 2p14 underlies autosomal dominant hearing loss DFNA58.
    Title: A rare genomic duplication in 2p14 underlies autosomal dominant hearing loss DFNA58.
  6. Tat-Cannabinoid Receptor Interacting Protein Reduces Ischemia-Induced Neuronal Damage and Its Possible Relationship with 14-3-3eta.
    Title: Tat-Cannabinoid Receptor Interacting Protein Reduces Ischemia-Induced Neuronal Damage and Its Possible Relationship with 14-3-3η.
  7. Through investigations of the function and structure of CRIP1a, new pharmacotherapies based upon the CRIP-CB1 receptor interaction can be designed to treat diseases such as epilepsy, motor dysfunctions and schizophrenia
    Title: Cannabinoid Receptor Interacting Protein 1a (CRIP1a): Function and Structure.
  8. The Arg82 and Cys126 of CRIP1b are involved in the majority of hydrogen bond interactions with the CB1 receptor and are possible key residues required for interactions between the CB1 receptor and CRIP1b
    Title: In silico interaction analysis of cannabinoid receptor interacting protein 1b (CRIP1b) - CB1 cannabinoid receptor.
  9. CNRIP1 and RUNX3 as potential DNA methylation biomarkers for CRC diagnosis and treatment
    Title: Screening of exon methylation biomarkers for colorectal cancer via LC-MS/MS strategy.
  10. CRIP1a can compete with beta-arrestins for interaction with C-terminal CB1R domains that could affect agonist-driven, beta-arrestin-mediated internalization of the CB1R.
    Title: Cannabinoid Receptor Interacting Protein 1a Competition with β-Arrestin for CB1 Receptor Binding Sites.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular cannabinoid receptor interacting protein 1 (CNRIP1) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp566K1924

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables type 1 cannabinoid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type 1 cannabinoid receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CB1 cannabinoid receptor-interacting protein 1
Names
cannabinoid receptor CB1-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111101.2 → NP_001104571.1  CB1 cannabinoid receptor-interacting protein 1 isoform CRIP1b

    See identical proteins and their annotated locations for NP_001104571.1

    Status: REVIEWED

    Source sequence(s)
    AC015969
    Consensus CDS
    CCDS46311.1
    UniProtKB/TrEMBL
    B8ZZB8
    Related
    ENSP00000386883.3, ENST00000409559.7
    Conserved Domains (1) summary
    pfam15043
    Location:4 → 110
    CNRIP1; CB1 cannabinoid receptor-interacting protein 1

  2. NM_001371604.1 → NP_001358533.1  CB1 cannabinoid receptor-interacting protein 1 isoform CRIP1a

    Status: REVIEWED

    Source sequence(s)
    AC015969
    Consensus CDS
    CCDS1886.1
    UniProtKB/Swiss-Prot
    B2R4D0, Q49AN4, Q96F85, Q9UFZ0
    Conserved Domains (1) summary
    pfam15043
    Location:4 → 158
    CNRIP1; CB1 cannabinoid receptor-interacting protein 1

  3. NM_001371605.1 → NP_001358534.1  CB1 cannabinoid receptor-interacting protein 1 isoform CRIP1a

    Status: REVIEWED

    Source sequence(s)
    AC015969
    Consensus CDS
    CCDS1886.1
    UniProtKB/Swiss-Prot
    B2R4D0, Q49AN4, Q96F85, Q9UFZ0
    Conserved Domains (1) summary
    pfam15043
    Location:4 → 158
    CNRIP1; CB1 cannabinoid receptor-interacting protein 1

  4. NM_001371606.1 → NP_001358535.1  CB1 cannabinoid receptor-interacting protein 1 isoform CRIP1a

    Status: REVIEWED

    Source sequence(s)
    AC015969
    Consensus CDS
    CCDS1886.1
    UniProtKB/Swiss-Prot
    B2R4D0, Q49AN4, Q96F85, Q9UFZ0
    Conserved Domains (1) summary
    pfam15043
    Location:4 → 158
    CNRIP1; CB1 cannabinoid receptor-interacting protein 1

  5. NM_001371607.1 → NP_001358536.1  CB1 cannabinoid receptor-interacting protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC015969
    Conserved Domains (1) summary
    pfam15043
    Location:26 → 129
    CNRIP1; CB1 cannabinoid receptor-interacting protein 1

  6. NM_001371608.1 → NP_001358537.1  CB1 cannabinoid receptor-interacting protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC015969
    Conserved Domains (1) summary
    pfam15043
    Location:26 → 129
    CNRIP1; CB1 cannabinoid receptor-interacting protein 1

  7. NM_015463.3 → NP_056278.1  CB1 cannabinoid receptor-interacting protein 1 isoform CRIP1a

    See identical proteins and their annotated locations for NP_056278.1

    Status: REVIEWED

    Source sequence(s)
    AC015969
    Consensus CDS
    CCDS1886.1
    UniProtKB/Swiss-Prot
    B2R4D0, Q49AN4, Q96F85, Q9UFZ0
    Related
    ENSP00000263655.3, ENST00000263655.4
    Conserved Domains (1) summary
    pfam15043
    Location:4 → 158
    CNRIP1; CB1 cannabinoid receptor-interacting protein 1

RNA

  1. NR_163969.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC015969

  2. NR_163970.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC015969
    Related
    ENST00000481714.1

  3. NR_163971.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC015969

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    68284171..68319949 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    68294742..68330519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96F85.1 GenPept UniProtKB/Swiss-Prot:Q96F85

Gene LinkOut

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