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Gpx6 glutathione peroxidase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 259233, updated on 21-Jul-2018

Summary

Official Symbol
Gpx6provided by RGD
Official Full Name
glutathione peroxidase 6provided by RGD
Primary source
RGD:628789
See related
Ensembl:ENSRNOG00000060749
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
OBPII; Ry2d1
Summary
This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidases catalyze the reduction of a variety of hydroperoxides using glutathione as a specific electron donor substrate, and thereby protect cells against oxidative damage. Expression of this gene is restricted to embryos and adult olfactory epithelium. The mouse and rat orthologs contain a cysteine (Cys) residue at the active site, unlike the human counterpart, which is a selenoprotein, containing selenocysteine (Sec) instead. [provided by RefSeq, Jul 2017]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Testes (RPKM 5.0), Brain (RPKM 0.8) and 1 other tissue See more
Orthologs

Genomic context

See Gpx6 in Genome Data Viewer
Location:
17q11
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (45439268..45446952, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (58020331..58027779)

Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene similar to BAF57 Neighboring gene transfer RNA threonine (anticodon CGU) Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene transfer RNA alanine (anticodon UGC)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glutathione peroxidase 6
Names
GPx-6
GSHPx-6
odorant-metabolizing protein RY2D1
NP_671694.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_147165.2NP_671694.1  glutathione peroxidase 6 precursor

    See identical proteins and their annotated locations for NP_671694.1

    Status: REVIEWED

    Source sequence(s)
    AABR07027826, M76733
    UniProtKB/Swiss-Prot
    Q64625
    Related
    ENSRNOP00000070342.1, ENSRNOT00000082782.1
    Conserved Domains (1) summary
    cd00340
    Location:39211
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

    Range
    45439268..45446952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000085.1 Alternate Rn_Celera

    Range
    53062670..53070210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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