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HSPA12A heat shock protein family A (Hsp70) member 12A [ Homo sapiens (human) ]

Gene ID: 259217, updated on 6-May-2021

Summary

Official Symbol
HSPA12Aprovided by HGNC
Official Full Name
heat shock protein family A (Hsp70) member 12Aprovided by HGNC
Primary source
HGNC:HGNC:19022
See related
Ensembl:ENSG00000165868 MIM:610701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in brain (RPKM 23.0), fat (RPKM 11.2) and 16 other tissues See more
Orthologs
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Genomic context

See HSPA12A in Genome Data Viewer
Location:
10q25.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (116671192..116853272, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118430703..118609233, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene pancreatic lipase related protein 2 (gene/pseudogene) Neighboring gene uncharacterized LOC105378499 Neighboring gene Sharpr-MPRA regulatory region 10762 Neighboring gene chromosome 10 open reading frame 82 Neighboring gene uncharacterized LOC105378498 Neighboring gene ribosomal protein L5 pseudogene 27 Neighboring gene Sharpr-MPRA regulatory region 690 Neighboring gene microRNA 9851 Neighboring gene enolase 4 Neighboring gene shootin 1 Neighboring gene VISTA enhancer hs841 Neighboring gene ventral anterior homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes.
GeneReviews: Not available
Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.
GeneReviews: Not available
Genome-wide association study of smoking behaviours in patients with COPD.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13874, KIAA0417

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heat shock 70 kDa protein 12A
Names
heat shock 70kD protein 12A
heat shock 70kDa protein 12A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330164.2NP_001317093.1  heat shock 70 kDa protein 12A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC016825, AC023283, AK294884, AL120441, BC041412, BM471679, DA416906, DC335324
    Consensus CDS
    CCDS81511.1
    UniProtKB/TrEMBL
    A0A1B0GTF3, B7Z2M8
    Related
    ENSP00000489674.1, ENST00000635765.1
    Conserved Domains (1) summary
    cd11735
    Location:74540
    HSPA12A_like_NBD; Nucleotide-binding domain of HSPA12A and similar proteins
  2. NM_025015.3NP_079291.2  heat shock 70 kDa protein 12A isoform 2

    See identical proteins and their annotated locations for NP_079291.2

    Status: VALIDATED

    Source sequence(s)
    AB007877, BU738372
    Consensus CDS
    CCDS41569.1
    UniProtKB/Swiss-Prot
    O43301
    Related
    ENSP00000358211.3, ENST00000369209.8
    Conserved Domains (1) summary
    cd11735
    Location:57523
    HSPA12A_like_NBD; Nucleotide-binding domain of HSPA12A and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    116671192..116853272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269673.5XP_005269730.1  heat shock 70 kDa protein 12A isoform X1

    See identical proteins and their annotated locations for XP_005269730.1

    Related
    ENSP00000501472.1, ENST00000674197.1
    Conserved Domains (1) summary
    cd11735
    Location:73539
    HSPA12A_like_NBD; Nucleotide-binding domain of HSPA12A and similar proteins
  2. XM_011539579.2XP_011537881.1  heat shock 70 kDa protein 12A isoform X1

    See identical proteins and their annotated locations for XP_011537881.1

    Conserved Domains (1) summary
    cd11735
    Location:73539
    HSPA12A_like_NBD; Nucleotide-binding domain of HSPA12A and similar proteins
  3. XM_017016032.2XP_016871521.1  heat shock 70 kDa protein 12A isoform X3

    Related
    ENSP00000501346.1, ENST00000674344.1
    Conserved Domains (1) summary
    cl17037
    Location:6347
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  4. XM_011539580.2XP_011537882.1  heat shock 70 kDa protein 12A isoform X2

    See identical proteins and their annotated locations for XP_011537882.1

    Related
    ENSP00000501445.1, ENST00000674459.1
    Conserved Domains (1) summary
    cl17037
    Location:1440
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
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