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NELFB negative elongation factor complex member B [ Homo sapiens (human) ]

Gene ID: 25920, updated on 7-Jun-2020

Summary

Official Symbol
NELFBprovided by HGNC
Official Full Name
negative elongation factor complex member Bprovided by HGNC
Primary source
HGNC:HGNC:24324
See related
Ensembl:ENSG00000188986 MIM:611180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COBRA1; NELF-B
Summary
NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 16.5), fat (RPKM 16.5) and 25 other tissues See more
Orthologs

Genomic context

See NELFB in Genome Data Viewer
Location:
9q34.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (137255327..137273542)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140149759..140168000)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene tubulin beta 4B class IVb Neighboring gene family with sequence similarity 166 member A Neighboring gene STPG3 antisense RNA 1 Neighboring gene sperm-tail PG-rich repeat containing 3 Neighboring gene torsin family 4 member A Neighboring gene 9q34.3 TOR4A distal recombination region

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of NELF-B by shRNA enhances HIV-1 transcription in latently infected cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat NELF represses HIV-1 transcription by pausing the RNA polymerase II complex PubMed
tat NELF associates with HIV-1 Tat as part of the HIV-1 transcription elongation complex PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • KIAA1182, DKFZp586B0519

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription elongation from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription elongation from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of viral transcription TAS
Traceable Author Statement
more info
 
stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
NELF complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NELF complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
negative elongation factor B
Names
cofactor of BRCA1
negative elongation factor protein B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015456.5NP_056271.3  negative elongation factor B

    Status: VALIDATED

    Source sequence(s)
    AK022651, AL050280, BC019029, DA210427
    Consensus CDS
    CCDS7040.2
    UniProtKB/Swiss-Prot
    Q8WX92
    Related
    ENSP00000339495.5, ENST00000343053.5
    Conserved Domains (1) summary
    pfam06209
    Location:155626
    COBRA1; Cofactor of BRCA1 (COBRA1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    137255327..137273542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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