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DPCD deleted in primary ciliary dyskinesia homolog (mouse) [ Homo sapiens (human) ]

Gene ID: 25911, updated on 24-Nov-2020

Summary

Official Symbol
DPCDprovided by HGNC
Official Full Name
deleted in primary ciliary dyskinesia homolog (mouse)provided by HGNC
Primary source
HGNC:HGNC:24542
See related
Ensembl:ENSG00000166171 MIM:616467
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene in mouse encodes a protein that may be involved in the generation and maintenance of ciliated cells. In mouse, expression of this gene increases during ciliated cell differentiation, and disruption of this gene has been linked to primary ciliary dyskinesia. [provided by RefSeq, Jul 2016]
Expression
Broad expression in testis (RPKM 51.1), kidney (RPKM 13.2) and 19 other tissues See more
Orthologs

Genomic context

See DPCD in Genome Data Viewer
Location:
10q24.32
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (101588321..101609662)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103330399..103369410)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene beta-transducin repeat containing E3 ubiquitin protein ligase Neighboring gene VISTA enhancer hs326 Neighboring gene microRNA 3158-1 Neighboring gene microRNA 3158-2 Neighboring gene DNA polymerase lambda Neighboring gene RNA, U6 small nuclear 1165, pseudogene Neighboring gene F-box and WD repeat domain containing 4 Neighboring gene uncharacterized LOC105378456 Neighboring gene uncharacterized LOC105378455

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp566F084

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
determination of left/right symmetry IEA
Inferred from Electronic Annotation
more info
 
epithelial cilium movement involved in extracellular fluid movement IEA
Inferred from Electronic Annotation
more info
 
flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
lateral ventricle development IEA
Inferred from Electronic Annotation
more info
 
left/right pattern formation IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
third ventricle development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
protein DPCD
Names
RP11-529I10.4
deleted in a mouse model of primary ciliary dyskinesia

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051289.1 RefSeqGene

    Range
    5034..26375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001329742.2NP_001316671.1  protein DPCD isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL627424, BX361465
  2. NM_001329743.2NP_001316672.1  protein DPCD isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL627424, DB475718
  3. NM_001329744.2NP_001316673.1  protein DPCD isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL627424, BM782340, BU681755
    Consensus CDS
    CCDS86141.1
    UniProtKB/TrEMBL
    Q5JQQ4
    Related
    ENSP00000359166.1, ENST00000370147.5
  4. NM_001329745.2NP_001316674.1  protein DPCD isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL627424
  5. NM_001329746.2NP_001316675.1  protein DPCD isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL627424
    Conserved Domains (1) summary
    pfam14913
    Location:650
    DPCD; DPCD protein family
  6. NM_015448.3NP_056263.1  protein DPCD isoform 2

    See identical proteins and their annotated locations for NP_056263.1

    Status: REVIEWED

    Source sequence(s)
    BC001082, BX361465, HY030728
    Consensus CDS
    CCDS7514.1
    UniProtKB/Swiss-Prot
    Q9BVM2
    Related
    ENSP00000359170.4, ENST00000370151.9
    Conserved Domains (1) summary
    pfam14913
    Location:6194
    DPCD; DPCD protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    101588321..101609662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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