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AHCTF1 AT-hook containing transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 25909, updated on 5-May-2024

Summary

Official Symbol
AHCTF1provided by HGNC
Official Full Name
AT-hook containing transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:24618
See related
Ensembl:ENSG00000153207 MIM:610853; AllianceGenome:HGNC:24618
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ELYS; MST108; TMBS62; MSTP108
Summary
Predicted to enable DNA binding activity. Involved in nuclear pore complex assembly and regulation of cytokinesis. Located in nuclear membrane. Colocalizes with chromatin; kinetochore; and nuclear pore outer ring. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 25.0), bone marrow (RPKM 11.9) and 25 other tissues See more
Orthologs
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Genomic context

See AHCTF1 in Genome Data Viewer
Location:
1q44
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (246839098..246931948, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (246270496..246363018, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (247002400..247095250, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:246939407-246940606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:246957595-246958236 Neighboring gene kinesin family member 28, pseudogene Neighboring gene long intergenic non-protein coding RNA 1341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2861 Neighboring gene MPRA-validated peak823 silencer Neighboring gene MPRA-validated peak824 silencer Neighboring gene MPRA-validated peak825 silencer Neighboring gene MPRA-validated peak826 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2863 Neighboring gene ZNF670-ZNF695 readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2865 Neighboring gene zinc finger protein 695 Neighboring gene Sharpr-MPRA regulatory region 11618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:247165417-247165917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2041 Neighboring gene zinc finger protein 519 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of AT hook containing transcription factor 1 (AHCTF1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp434N093

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in nuclear pore complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
colocalizes_with kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pore NAS
Non-traceable Author Statement
more info
PubMed 
part_of nuclear pore outer ring IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein ELYS
Names
ELYS transcription factor-like protein TMBS62
embryonic large molecule derived from yolk sac
putative AT-hook-containing transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323342.2NP_001310271.1  protein ELYS isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113174
    Consensus CDS
    CCDS91190.1
    UniProtKB/Swiss-Prot
    A6NGM0, A8MSG9, A8MZ86, Q7Z4E3, Q8IZA4, Q8WYP5, Q96EH9, Q9Y4Q6
    Related
    ENSP00000497061.2, ENST00000648844.2
    Conserved Domains (4) summary
    pfam09528
    Location:16372003
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    pfam13934
    Location:722947
    ELYS; Nuclear pore complex assembly
    pfam16687
    Location:2489
    ELYS-bb; beta-propeller of ELYS nucleoporin
    sd00039
    Location:223259
    7WD40; WD40 repeat [structural motif]
  2. NM_001323343.2NP_001310272.1  protein ELYS isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113174
  3. NM_001410950.1NP_001397879.1  protein ELYS isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113174
    Consensus CDS
    CCDS91191.1
    Related
    ENSP00000355464.1, ENST00000366508.5
  4. NM_015446.5NP_056261.4  protein ELYS isoform 1

    Status: VALIDATED

    Source sequence(s)
    AB059277, AC113174, BC012307
    Consensus CDS
    CCDS1629.2
    UniProtKB/Swiss-Prot
    Q8WYP5
    Related
    ENSP00000355465.1, ENST00000326225.3
    Conserved Domains (4) summary
    pfam09528
    Location:16462012
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    pfam13934
    Location:731956
    ELYS; Nuclear pore complex assembly
    pfam16687
    Location:11498
    ELYS-bb; beta-propeller of ELYS nucleoporin
    sd00039
    Location:232268
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_136586.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113174

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    246839098..246931948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544157.4XP_011542459.3  protein ELYS isoform X2

  2. XM_011544156.3XP_011542458.3  protein ELYS isoform X1

  3. XM_047417231.1XP_047273187.1  protein ELYS isoform X3

  4. XM_047417232.1XP_047273188.1  protein ELYS isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    246270496..246363018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335862.1XP_054191837.1  protein ELYS isoform X2

  2. XM_054335861.1XP_054191836.1  protein ELYS isoform X1

  3. XM_054335863.1XP_054191838.1  protein ELYS isoform X3

  4. XM_054335864.1XP_054191839.1  protein ELYS isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175865.1: Suppressed sequence

    Description
    NM_175865.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.