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AHCTF1 AT-hook containing transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 25909, updated on 15-Jun-2019

Summary

Official Symbol
AHCTF1provided by HGNC
Official Full Name
AT-hook containing transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:24618
See related
Ensembl:ENSG00000153207 MIM:610853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ELYS; MST108; TMBS62; MSTP108
Expression
Broad expression in testis (RPKM 25.0), bone marrow (RPKM 11.9) and 25 other tissues See more
Orthologs

Genomic context

See AHCTF1 in Genome Data Viewer
Location:
1q44
Exon count:
39
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (246839098..246931978, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (247002400..247094726, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene kinesin family member 28, pseudogene Neighboring gene long intergenic non-protein coding RNA 1341 Neighboring gene ZNF670-ZNF695 readthrough (NMD candidate) Neighboring gene zinc finger protein 695 Neighboring gene zinc finger protein 519 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of AT hook containing transcription factor 1 (AHCTF1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Gastric Cancer Network 2, organism-specific biosystem (from WikiPathways)
    Gastric Cancer Network 2, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Network generated by Ingenuity Pathway Analysis.
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434N093

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
nuclear pore complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with chromatin IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with condensed chromosome kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
colocalizes_with nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nuclear pore outer ring IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein ELYS
Names
ELYS transcription factor-like protein TMBS62
embryonic large molecule derived from yolk sac
putative AT-hook-containing transcription factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323342.2NP_001310271.1  protein ELYS isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113174
    UniProtKB/Swiss-Prot
    Q8WYP5
    Related
    ENSP00000497061.1, ENST00000648844.1
    Conserved Domains (4) summary
    pfam09528
    Location:16372003
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    pfam13934
    Location:722947
    ELYS; Nuclear pore complex assembly
    pfam16687
    Location:2489
    ELYS-bb; beta-propeller of ELYS nucleoporin
    sd00039
    Location:223259
    7WD40; WD40 repeat [structural motif]
  2. NM_001323343.2NP_001310272.1  protein ELYS isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113174
  3. NM_015446.5NP_056261.4  protein ELYS isoform 1

    Status: VALIDATED

    Source sequence(s)
    AB059277, AC113174, BC012307
    Consensus CDS
    CCDS1629.2
    UniProtKB/Swiss-Prot
    Q8WYP5
    Related
    ENSP00000355465.1, ENST00000326225.3
    Conserved Domains (4) summary
    pfam09528
    Location:16462012
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    pfam13934
    Location:731956
    ELYS; Nuclear pore complex assembly
    pfam16687
    Location:11498
    ELYS-bb; beta-propeller of ELYS nucleoporin
    sd00039
    Location:232268
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_136586.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113174

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    246839098..246931978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711758.1XP_006711821.1  protein ELYS isoform X1

    UniProtKB/Swiss-Prot
    Q8WYP5
    Related
    ENSP00000355464.1, ENST00000366508.5
    Conserved Domains (4) summary
    pfam09528
    Location:16722038
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    pfam13934
    Location:757982
    ELYS; Nuclear pore complex assembly
    pfam16687
    Location:37524
    ELYS-bb; beta-propeller of ELYS nucleoporin
    sd00039
    Location:258294
    7WD40; WD40 repeat [structural motif]
  2. XM_011544157.3XP_011542459.2  protein ELYS isoform X3

  3. XM_011544156.2XP_011542458.2  protein ELYS isoform X2

RNA

  1. XR_949136.3 RNA Sequence

  2. XR_426916.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175865.1: Suppressed sequence

    Description
    NM_175865.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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