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TMEM158 transmembrane protein 158 [ Homo sapiens (human) ]

Gene ID: 25907, updated on 1-Jun-2020

Summary

Official Symbol
TMEM158provided by HGNC
Official Full Name
transmembrane protein 158provided by HGNC
Primary source
HGNC:HGNC:30293
See related
Ensembl:ENSG00000249992
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BBP; RIS1; p40BBP
Summary
Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. An allelic polymorphism in this gene results in both functional and non-functional (frameshifted) alleles; the reference genome represents the functional allele. [provided by RefSeq, Jul 2015]
Orthologs

Genomic context

See TMEM158 in Genome Data Viewer
Location:
3p21.31
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (45224466..45226287, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (45265956..45267814, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S24 pseudogene 8 Neighboring gene uncharacterized LOC101928636 Neighboring gene uncharacterized LOC105377061 Neighboring gene uncharacterized LOC105377062 Neighboring gene leucyl-tRNA synthetase 2, mitochondrial Neighboring gene LARS2 antisense RNA 1

Genomic regions, transcripts, and products

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

General gene information

Markers

Homology

Clone Names

  • DKFZp586E1621

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 158
Names
40 kDa BINP-binding protein
BINP receptor
Ras induced senescence 1
brain injury-derived neurotrophic peptide (BINP) binding protein
brain specific binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015444.3NP_056259.2  transmembrane protein 158 precursor

    See identical proteins and their annotated locations for NP_056259.2

    Status: REVIEWED

    Source sequence(s)
    AF438313, BQ000094, BU627971, BX401325, BX459891
    Consensus CDS
    CCDS54573.1
    UniProtKB/Swiss-Prot
    Q8WZ71
    Related
    ENSP00000422431.1, ENST00000503771.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    45224466..45226287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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