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MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like [ Homo sapiens (human) ]

Gene ID: 25902, updated on 4-Apr-2021

Summary

Official Symbol
MTHFD1Lprovided by HGNC
Official Full Name
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 likeprovided by HGNC
Primary source
HGNC:HGNC:21055
See related
Ensembl:ENSG00000120254 MIM:611427
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FTHFSDC1; MTC1THFS; dJ292B18.2
Summary
The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in ovary (RPKM 2.3), thyroid (RPKM 2.0) and 25 other tissues See more
Orthologs
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Genomic context

See MTHFD1L in Genome Data Viewer
Location:
6q25.1
Exon count:
42
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (150865684..151101887)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (151186838..151423023)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene PLEKHG1 intron CAGE-defined B cell enhancer Neighboring gene pleckstrin homology and RhoGEF domain containing G1 Neighboring gene PDCL3 pseudogene 5 Neighboring gene RNA, U6 small nuclear 302, pseudogene Neighboring gene ADP ribosylation factor like GTPase 4A pseudogene 5 Neighboring gene ribosomal protein L32 pseudogene 16 Neighboring gene microRNA 12131 Neighboring gene uncharacterized LOC102723831 Neighboring gene RNA, U6 small nuclear 300, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia.
GeneReviews: Not available
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
GeneReviews: Not available
Genomewide association analysis of coronary artery disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif interacts with MTHFD1L; interaction predicted to be relevant to purine pyrimidine biosynthesis PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21145, DKFZp586G1517

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
formate-tetrahydrofolate ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
10-formyltetrahydrofolate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
embryonic neurocranium morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic viscerocranium morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
folic acid metabolic process TAS
Traceable Author Statement
more info
 
folic acid-containing compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
formate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
neural tube closure ISS
Inferred from Sequence or Structural Similarity
more info
 
tetrahydrofolate interconversion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
monofunctional C1-tetrahydrofolate synthase, mitochondrial
Names
10-formyl-THF synthetase
formyltetrahydrofolate synthetase domain containing 1
NP_001229696.1
NP_001229697.1
NP_001229698.1
NP_001337415.1
NP_001337416.1
NP_001337417.1
NP_001337418.1
NP_001337419.1
NP_001337420.1
NP_001337421.1
NP_001337422.1
NP_056255.2
XP_005266964.1
XP_005266968.1
XP_011534031.1
XP_011534032.1
XP_011534033.1
XP_011534034.1
XP_011534035.1
XP_011534036.1
XP_011534039.1
XP_011534040.1
XP_016866191.1
XP_016866192.1
XP_016866194.1
XP_024302163.1
XP_024302164.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029185.2 RefSeqGene

    Range
    5001..241209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242767.2NP_001229696.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_001229696.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC110319, BC144368, DB727926
    Consensus CDS
    CCDS75535.1
    UniProtKB/Swiss-Prot
    Q6UB35
    UniProtKB/TrEMBL
    B7ZM99
    Related
    ENSP00000478253.1, ENST00000611279.4
    Conserved Domains (4) summary
    cd05212
    Location:193336
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:353979
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:72289
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:74180
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  2. NM_001242768.2NP_001229697.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK315378, BC110319, DA195967
    Consensus CDS
    CCDS75536.1
    UniProtKB/Swiss-Prot
    Q6UB35
    UniProtKB/TrEMBL
    A0A087WVM4, B2RD24
    Related
    ENSP00000479539.1, ENST00000618312.4
    Conserved Domains (4) summary
    cd05212
    Location:127270
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:287913
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:9223
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:10114
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  3. NM_001242769.3NP_001229698.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 4 precursor

    See identical proteins and their annotated locations for NP_001229698.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus and lacks a single internal aa compared to isoform 1. Isoform 4 is thought to lack THF synthase activity.
    Source sequence(s)
    AW593866, AY374131, DB727926
    Consensus CDS
    CCDS56457.1
    UniProtKB/Swiss-Prot
    Q6UB35
    Related
    ENSP00000356276.4, ENST00000367307.8
    Conserved Domains (3) summary
    COG0190
    Location:72228
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:74180
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    cl21454
    Location:193260
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. NM_001350486.1NP_001337415.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL035086, AL049694, AL133260
    Conserved Domains (3) summary
    cd05212
    Location:127269
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:286912
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:9222
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
  5. NM_001350487.2NP_001337416.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL035086, AL049694, AL133260
    Conserved Domains (3) summary
    cd05212
    Location:83225
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:242868
    PLN02759; Formate--tetrahydrofolate ligase
    pfam00763
    Location:970
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  6. NM_001350488.3NP_001337417.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AL035086
    Conserved Domains (2) summary
    COG0190
    Location:72229
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    cl25423
    Location:193261
    NAD_bind_amino_acid_DH; NAD(P) binding domain of amino acid dehydrogenase-like proteins
  7. NM_001350489.3NP_001337418.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AL035086
    Conserved Domains (1) summary
    COG0190
    Location:72213
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
  8. NM_001350490.1NP_001337419.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL049694, AL133260
    Conserved Domains (1) summary
    cl21455
    Location:2270
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  9. NM_001350491.3NP_001337420.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL035086
    Conserved Domains (2) summary
    COG0190
    Location:9119
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    cl21454
    Location:83151
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  10. NM_001350492.2NP_001337421.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 12, encodes isoform 11.
    Source sequence(s)
    AL035086, AL049694, AL133260
    Conserved Domains (3) summary
    cd05212
    Location:83226
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:243869
    PLN02759; Formate--tetrahydrofolate ligase
    pfam00763
    Location:970
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  11. NM_001350493.1NP_001337422.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variant 11, encodes isoform 11.
    Source sequence(s)
    AL035086, AL049694, AL133260
    Conserved Domains (3) summary
    cd05212
    Location:83226
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:243869
    PLN02759; Formate--tetrahydrofolate ligase
    pfam00763
    Location:970
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  12. NM_015440.5NP_056255.2  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_056255.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AY374130, BC110319, DB727926
    Consensus CDS
    CCDS5228.1
    UniProtKB/Swiss-Prot
    Q6UB35
    Related
    ENSP00000356290.3, ENST00000367321.7
    Conserved Domains (4) summary
    cd05212
    Location:193335
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:352978
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:72288
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:74180
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

RNA

  1. NR_146719.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL035086, AL049694, AL133260
  2. NR_146720.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL035086, AL049694, AL133260

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    150865684..151101887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010702.2XP_016866191.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    B7ZM99
    Conserved Domains (4) summary
    cd05212
    Location:193336
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:353979
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:72289
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:74180
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  2. XM_017010703.2XP_016866192.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    B7ZM99
    Conserved Domains (4) summary
    cd05212
    Location:193336
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:353979
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:72289
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:74180
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  3. XM_011535729.3XP_011534031.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X3

    Conserved Domains (4) summary
    cd05212
    Location:193336
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:353952
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:72289
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:74180
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  4. XM_005266907.5XP_005266964.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1

    Conserved Domains (4) summary
    cd05212
    Location:193335
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:352949
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:72288
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:74180
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  5. XM_011535737.3XP_011534039.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X9

    Conserved Domains (4) summary
    cd05212
    Location:193336
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    COG0190
    Location:72289
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:74180
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    cl21455
    Location:353709
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_011535738.3XP_011534040.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X10

    Conserved Domains (4) summary
    cd05212
    Location:193336
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    COG0190
    Location:72289
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:74180
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    cl21455
    Location:353709
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  7. XM_005266911.5XP_005266968.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X11

    Conserved Domains (4) summary
    cd05212
    Location:193336
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    COG0190
    Location:72289
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:74180
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    cl21455
    Location:353605
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  8. XM_024446396.1XP_024302164.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X12

    Conserved Domains (3) summary
    cd05212
    Location:193336
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    COG0190
    Location:72289
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    cl21455
    Location:353420
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  9. XM_011535730.2XP_011534032.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X5

    Conserved Domains (4) summary
    cd05212
    Location:127270
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:287884
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:9223
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:10114
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  10. XM_011535731.2XP_011534033.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X6

    Conserved Domains (4) summary
    cd05212
    Location:127269
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:286883
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:9222
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:10114
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  11. XM_011535734.2XP_011534036.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X8

    Conserved Domains (4) summary
    cd05212
    Location:83225
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:242839
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:9178
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:970
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  12. XM_011535732.2XP_011534034.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X7

    See identical proteins and their annotated locations for XP_011534034.1

    Conserved Domains (4) summary
    cd05212
    Location:83226
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:243840
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:9179
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:970
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  13. XM_024446395.1XP_024302163.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X4

    Conserved Domains (3) summary
    cd05212
    Location:158300
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:317943
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:40253
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
  14. XM_011535733.2XP_011534035.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X7

    See identical proteins and their annotated locations for XP_011534035.1

    Conserved Domains (4) summary
    cd05212
    Location:83226
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:243840
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:9179
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:970
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
  15. XM_017010705.1XP_016866194.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X8

    Conserved Domains (4) summary
    cd05212
    Location:83225
    NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    PLN02759
    Location:242839
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:9178
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:970
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

RNA

  1. XR_002956274.1 RNA Sequence

  2. XR_001743322.2 RNA Sequence

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