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INTS7 integrator complex subunit 7 [ Homo sapiens (human) ]

Gene ID: 25896, updated on 1-Jun-2020

Summary

Official Symbol
INTS7provided by HGNC
Official Full Name
integrator complex subunit 7provided by HGNC
Primary source
HGNC:HGNC:24484
See related
Ensembl:ENSG00000143493 MIM:611350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT7; C1orf73
Summary
This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Expression
Broad expression in testis (RPKM 9.9), lymph node (RPKM 3.5) and 24 other tissues See more
Orthologs

Genomic context

See INTS7 in Genome Data Viewer
Location:
1q32.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (211940328..212035660, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (212113741..212209002, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene lysophosphatidylglycerol acyltransferase 1 Neighboring gene RNA, 7SL, cytoplasmic 344, pseudogene Neighboring gene LPGAT1 antisense RNA 1 Neighboring gene ribosomal protein L21 pseudogene 28 Neighboring gene denticleless E3 ubiquitin protein ligase homolog Neighboring gene microRNA 3122

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
NHGRI GWA Catalog
Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of integrator complex subunit 7 (INTS7) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434B168

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to ionizing radiation IDA
Inferred from Direct Assay
more info
PubMed 
snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
snRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
chromosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrator complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
integrator complex subunit 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199809.1NP_001186738.1  integrator complex subunit 7 isoform 4

    See identical proteins and their annotated locations for NP_001186738.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AC092814, AK001598, AK297225, BC009918, DB062625
    Consensus CDS
    CCDS55683.1
    UniProtKB/Swiss-Prot
    Q9NVH2
    Related
    ENSP00000388908.2, ENST00000440600.6
  2. NM_001199811.1NP_001186740.1  integrator complex subunit 7 isoform 2

    See identical proteins and their annotated locations for NP_001186740.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC092814, BC009918, BC020523, DB062625
    Consensus CDS
    CCDS55685.1
    UniProtKB/Swiss-Prot
    Q9NVH2
    Related
    ENSP00000355960.3, ENST00000366993.7
  3. NM_001199812.1NP_001186741.1  integrator complex subunit 7 isoform 3

    See identical proteins and their annotated locations for NP_001186741.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC092814, AK001363, BC009918, DB062625
    Consensus CDS
    CCDS55684.1
    UniProtKB/Swiss-Prot
    Q9NVH2
    Related
    ENSP00000355959.3, ENST00000366992.7
  4. NM_015434.4NP_056249.1  integrator complex subunit 7 isoform 1

    See identical proteins and their annotated locations for NP_056249.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC092814, AK001598, BC009918, DB062625
    Consensus CDS
    CCDS1501.1
    UniProtKB/Swiss-Prot
    Q9NVH2
    Related
    ENSP00000355961.3, ENST00000366994.8

RNA

  1. NR_037667.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC092814, BC009918, DB062625
    Related
    ENST00000469606.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    211940328..212035660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509396.2XP_011507698.1  integrator complex subunit 7 isoform X1

  2. XM_017000962.1XP_016856451.1  integrator complex subunit 7 isoform X2

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