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EEF1AKMT3 EEF1A lysine methyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 25895, updated on 1-Oct-2022

Summary

Official Symbol
EEF1AKMT3provided by HGNC
Official Full Name
EEF1A lysine methyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:24936
See related
Ensembl:ENSG00000123427 MIM:615258; AllianceGenome:HGNC:24936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM119B; METTL21B
Summary
Enables heat shock protein binding activity and protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Located in several cellular components, including centrosome; chromosome; and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 5.3), ovary (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

See EEF1AKMT3 in Genome Data Viewer
Location:
12q14.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (57772614..57782541)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (57740963..57750909)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (58166397..58176324)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 27 subfamily B member 1 Neighboring gene methyltransferase 1, tRNA methylguanosine Neighboring gene Ts translation elongation factor, mitochondrial Neighboring gene advillin Neighboring gene RNA, U6 small nuclear 1083, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TSFM

Homology

Clone Names

  • DKFZp586D0919

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-lysine N-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in peptidyl-lysine methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-lysine methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-lysine methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
EEF1A lysine methyltransferase 3
Names
eEF1A-KMT3
family with sequence similarity 119, member B
hepatocellular carcinoma-associated antigen 557a
hepatocellularcarcinoma-associated antigen HCA557a
methyltransferase like 21B
methyltransferase-like protein 21B
protein-lysine methyltransferase METTL21B
NP_056248.2
NP_996797.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015433.3NP_056248.2  EEF1A lysine methyltransferase 3 isoform a

    See identical proteins and their annotated locations for NP_056248.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL050100, BC016395
    Consensus CDS
    CCDS8957.1
    UniProtKB/Swiss-Prot
    Q96AZ1, Q9Y3W2
    Related
    ENSP00000300209.8, ENST00000300209.13
    Conserved Domains (1) summary
    cl17173
    Location:37195
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_206914.2NP_996797.1  EEF1A lysine methyltransferase 3 isoform b

    See identical proteins and their annotated locations for NP_996797.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL050100, BC016395
    Consensus CDS
    CCDS31848.1
    UniProtKB/Swiss-Prot
    Q96AZ1
    Related
    ENSP00000327425.5, ENST00000333012.5
    Conserved Domains (1) summary
    cl17173
    Location:37111
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    57772614..57782541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    57740963..57750909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)