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TRIM58 tripartite motif containing 58 [ Homo sapiens (human) ]

Gene ID: 25893, updated on 6-Nov-2022

Summary

Official Symbol
TRIM58provided by HGNC
Official Full Name
tripartite motif containing 58provided by HGNC
Primary source
HGNC:HGNC:24150
See related
Ensembl:ENSG00000162722 AllianceGenome:HGNC:24150
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIA2
Summary
Predicted to enable dynein heavy chain binding activity; dynein intermediate chain binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of erythrocyte enucleation; protein ubiquitination; and regulation of nuclear migration along microtubule. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bone marrow (RPKM 12.4), thyroid (RPKM 11.2) and 5 other tissues See more
Orthologs
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Genomic context

See TRIM58 in Genome Data Viewer
Location:
1q44
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (247857187..247880138)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (247288019..247311943)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (248020489..248043440)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 11 subfamily L member 1 Neighboring gene CRISPRi-validated cis-regulatory element chr1.12967 Neighboring gene olfactory receptor family 2 subfamily W member 3 Neighboring gene olfactory receptor family 2 subfamily T member 8

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog
New gene functions in megakaryopoiesis and platelet formation.
EBI GWAS Catalog
Seventy-five genetic loci influencing the human red blood cell.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tripartite motif containing 58 (TRIM58) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434C091, DKFZp686N09198

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dynein heavy chain binding IEA
Inferred from Electronic Annotation
more info
 
enables dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of erythrocyte enucleation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autoubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of nuclear migration along microtubule IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM58
Names
RING-type E3 ubiquitin transferase TRIM58
tripartite motif-containing protein 58
NP_056246.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015431.4NP_056246.3  E3 ubiquitin-protein ligase TRIM58

    See identical proteins and their annotated locations for NP_056246.3

    Status: VALIDATED

    Source sequence(s)
    AC099571, AF327057, BX644877, DN998591
    Consensus CDS
    CCDS1636.1
    UniProtKB/Swiss-Prot
    Q6B0H9, Q8NG06
    Related
    ENSP00000355437.3, ENST00000366481.4
    Conserved Domains (4) summary
    smart00336
    Location:93132
    BBOX; B-Box-type zinc finger
    pfam13863
    Location:143242
    DUF4200; Domain of unknown function (DUF4200)
    pfam15227
    Location:1660
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15816
    Location:292459
    SPRY_PRY_TRIM58; PRY/SPRY domain in tripartite motif-binding protein 58 (TRIM58), also known as BIA2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    247857187..247880138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    247288019..247311943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)