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ZNF473 zinc finger protein 473 [ Homo sapiens (human) ]

Gene ID: 25888, updated on 9-Dec-2018

Summary

Official Symbol
ZNF473provided by HGNC
Official Full Name
zinc finger protein 473provided by HGNC
Primary source
HGNC:HGNC:23239
See related
Ensembl:ENSG00000142528 MIM:617908
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZN473; ZFP100
Summary
This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3'-end pre-mRNA processing and may be required for cell cycle progression to S phase. Expression level and methylation status of this gene may be correlated with bone mineral density. [provided by RefSeq, Jul 2016]
Expression
Broad expression in testis (RPKM 14.8), spleen (RPKM 2.3) and 21 other tissues See more
Orthologs

Genomic context

See ZNF473 in Genome Data Viewer
Location:
19q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (50025893..50048776)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50528786..50552033)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sialic acid binding Ig like lectin 16 (gene/pseudogene) Neighboring gene VRK serine/threonine kinase 3 Neighboring gene uncharacterized LOC400710 Neighboring gene zinc finger protein 420-like Neighboring gene small NF90 (ILF3) associated RNA A4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
histone mRNA metabolic process TAS
Traceable Author Statement
more info
 
mRNA 3'-end processing by stem-loop binding and cleavage IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
termination of RNA polymerase II transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 473
Names
zinc finger protein 100 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051198.1 RefSeqGene

    Range
    5088..27971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001006656.3NP_001006657.1  zinc finger protein 473 isoform 1

    See identical proteins and their annotated locations for NP_001006657.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode isoform 1.
    Source sequence(s)
    AB032967, AF454744, AL080143, DB086543
    Consensus CDS
    CCDS33077.1
    UniProtKB/Swiss-Prot
    Q8WTR7
    UniProtKB/TrEMBL
    A0A024QZI1
    Related
    ENSP00000375697.1, ENST00000391821.6
    Conserved Domains (3) summary
    cd07765
    Location:645
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:457860
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:732752
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001308424.2NP_001295353.1  zinc finger protein 473 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' UTR and 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AB032967, AK302293, AL080143, BC018612, DB086543
    Consensus CDS
    CCDS77335.1
    UniProtKB/Swiss-Prot
    Q8WTR7
    UniProtKB/TrEMBL
    B4DY71, F8WEC7
    Related
    ENSP00000388961.2, ENST00000445728.7
    Conserved Domains (4) summary
    COG5048
    Location:445848
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:720740
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:732757
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:133
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  3. NM_015428.4NP_056243.1  zinc finger protein 473 isoform 1

    See identical proteins and their annotated locations for NP_056243.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AB032967, AF454744, AL080143, BX492803
    Consensus CDS
    CCDS33077.1
    UniProtKB/Swiss-Prot
    Q8WTR7
    UniProtKB/TrEMBL
    A0A024QZI1
    Related
    ENSP00000270617.3, ENST00000270617.7
    Conserved Domains (3) summary
    cd07765
    Location:645
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:457860
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:732752
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    50025893..50048776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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