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TMEM186 transmembrane protein 186 [ Homo sapiens (human) ]

Gene ID: 25880, updated on 23-Nov-2023

Summary

Official Symbol
TMEM186provided by HGNC
Official Full Name
transmembrane protein 186provided by HGNC
Primary source
HGNC:HGNC:24530
See related
Ensembl:ENSG00000184857 MIM:620433; AllianceGenome:HGNC:24530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C16orf51
Summary
This gene encodes a potential transmembrane protein. [provided by RefSeq, Dec 2012]
Expression
Ubiquitous expression in kidney (RPKM 5.1), colon (RPKM 4.7) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM186 in Genome Data Viewer
Location:
16p13.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (8795180..8797639, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (8827933..8830391, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (8889037..8891496, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene 4-aminobutyrate aminotransferase Neighboring gene RNA, U7 small nuclear 63 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8813960-8814460 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:8821022-8821250 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:8825911-8826496 Neighboring gene uncharacterized LOC107984840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8845208-8845952 Neighboring gene uncharacterized LOC124903642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7177 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8891090-8891784 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8891785-8892479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7180 Neighboring gene phosphomannomutase 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8923335-8923936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:8929774-8930308 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:8930309-8930841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8940347-8940938 Neighboring gene uncharacterized LOC100130283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8953773-8954487 Neighboring gene calcium regulated heat stable protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp564K2062

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033146.1 RefSeqGene

    Range
    5010..7469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015421.4NP_056236.2  transmembrane protein 186

    See identical proteins and their annotated locations for NP_056236.2

    Status: VALIDATED

    Source sequence(s)
    AC012173, BG682191, CA433910
    Consensus CDS
    CCDS10535.1
    UniProtKB/Swiss-Prot
    B2RAY0, Q96B77, Q9Y4T4
    Related
    ENSP00000331640.6, ENST00000333050.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    8795180..8797639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    8827933..8830391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)