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DCAF13 DDB1 and CUL4 associated factor 13 [ Homo sapiens (human) ]

Gene ID: 25879, updated on 8-Aug-2021

Summary

Official Symbol
DCAF13provided by HGNC
Official Full Name
DDB1 and CUL4 associated factor 13provided by HGNC
Primary source
HGNC:HGNC:24535
See related
Ensembl:ENSG00000164934 MIM:616196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GM83; Sof1; WDSOF1; HSPC064
Expression
Ubiquitous expression in testis (RPKM 16.5), kidney (RPKM 11.1) and 25 other tissues See more
Orthologs
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Genomic context

See DCAF13 in Genome Data Viewer
Location:
8q22.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (103415386..103443453)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (104427614..104455681)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1011, pseudogene Neighboring gene solute carrier family 25 member 32 Neighboring gene uncharacterized LOC105375690 Neighboring gene Sharpr-MPRA regulatory region 6081 Neighboring gene regulating synaptic membrane exocytosis 2 Neighboring gene prothymosin alpha pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126859, MGC138247, DKFZp564O0463

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DDB1- and CUL4-associated factor 13
Names
WD repeat and SOF domain-containing protein 1
WD repeats and SOF1 domain containing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015420.7NP_056235.5  DDB1- and CUL4-associated factor 13

    Status: VALIDATED

    Source sequence(s)
    AC012213, AK027799, CA429438
    Consensus CDS
    CCDS34934.1
    Related
    ENSP00000484962.1, ENST00000612750.5
    Conserved Domains (3) summary
    cd00200
    Location:59353
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:70107
    7WD40; WD40 repeat [structural motif]
    pfam04158
    Location:354435
    Sof1; Sof1-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    103415386..103443453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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