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MXRA5 matrix remodeling associated 5 [ Homo sapiens (human) ]

Gene ID: 25878, updated on 11-Jun-2021

Summary

Official Symbol
MXRA5provided by HGNC
Official Full Name
matrix remodeling associated 5provided by HGNC
Primary source
HGNC:HGNC:7539
See related
Ensembl:ENSG00000101825 MIM:300938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in skin (RPKM 16.1), urinary bladder (RPKM 11.0) and 22 other tissues See more
Orthologs
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Genomic context

See MXRA5 in Genome Data Viewer
Location:
Xp22.33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (3308565..3346652, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (3226606..3264693, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S24 pseudogene 21 Neighboring gene long intergenic non-protein coding RNA 1546 Neighboring gene argininosuccinate synthetase 1 pseudogene 4 Neighboring gene small nucleolar RNA, H/ACA box 48B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetically distinct subsets within ANCA-associated vasculitis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564I1922

General protein information

Preferred Names
matrix-remodeling-associated protein 5
Names
adhesion protein with leucine-rich repeats and Immunoglobulin domains related to perlecan
adlican
matrix-remodelling associated 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021336.1 RefSeqGene

    Range
    4992..43079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015419.4NP_056234.2  matrix-remodeling-associated protein 5 precursor

    See identical proteins and their annotated locations for NP_056234.2

    Status: REVIEWED

    Source sequence(s)
    AC004616, AF245505, BC064986, CD626974
    Consensus CDS
    CCDS14124.1
    UniProtKB/Swiss-Prot
    Q9NR99
    Related
    ENSP00000217939.5, ENST00000217939.7
    Conserved Domains (10) summary
    cd00096
    Location:27512824
    Ig; Immunoglobulin domain
    smart00408
    Location:19652032
    IGc2; Immunoglobulin C-2 Type
    smart00082
    Location:217263
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:25492633
    IG; Immunoglobulin
    smart00410
    Location:23562435
    IG_like; Immunoglobulin like
    pfam07679
    Location:19582042
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:3855
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:128168
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:102163
    LRR_8; Leucine rich repeat
    cl11960
    Location:23612435
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    3308565..3346652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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