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MPC2 mitochondrial pyruvate carrier 2 [ Homo sapiens (human) ]

Gene ID: 25874, updated on 26-Jan-2024

Summary

Official Symbol
MPC2provided by HGNC
Official Full Name
mitochondrial pyruvate carrier 2provided by HGNC
Primary source
HGNC:HGNC:24515
See related
Ensembl:ENSG00000143158 MIM:614737; AllianceGenome:HGNC:24515
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRP44; SLC54A2
Summary
Enables identical protein binding activity. Predicted to be involved in mitochondrial pyruvate transmembrane transport. Predicted to act upstream of or within mitochondrial acetyl-CoA biosynthetic process from pyruvate and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney (RPKM 34.8), liver (RPKM 32.8) and 25 other tissues See more
Orthologs
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Genomic context

See MPC2 in Genome Data Viewer
Location:
1q24.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (167916675..167937072, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (167268139..167288538, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (167885913..167906310, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1535 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:167691547-167692047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167697263-167697762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2053 Neighboring gene myelin protein zero like 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:167739237-167739808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167740743-167741244 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:167761820-167761968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1538 Neighboring gene adenylate cyclase 10 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:167830579-167831095 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:167831096-167831613 Neighboring gene Sharpr-MPRA regulatory region 4419 Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:167882400-167883076 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:167883077-167883753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1541 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:167956130-167957329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2056 Neighboring gene microRNA 1255b-2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:168025104-168025604 Neighboring gene GCSH pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC125752, MGC125753, DKFZp564B167

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables pyruvate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of inner mitochondrial membrane protein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
mitochondrial pyruvate carrier 2
Names
brain protein 44

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143674.4NP_001137146.1  mitochondrial pyruvate carrier 2

    See identical proteins and their annotated locations for NP_001137146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes a functional protein. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL035304, KF455056, Z97876
    Consensus CDS
    CCDS1266.1
    UniProtKB/Swiss-Prot
    A8K261, O95563, Q3SXR6, Q6FIF3
    UniProtKB/TrEMBL
    B2R4Q7
    Related
    ENSP00000271373.4, ENST00000271373.9
    Conserved Domains (1) summary
    pfam03650
    Location:27125
    MPC; Uncharacterized protein family (UPF0041)
  2. NM_015415.3NP_056230.1  mitochondrial pyruvate carrier 2

    See identical proteins and their annotated locations for NP_056230.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL554033, KF455056, Z97876
    Consensus CDS
    CCDS1266.1
    UniProtKB/Swiss-Prot
    A8K261, O95563, Q3SXR6, Q6FIF3
    UniProtKB/TrEMBL
    B2R4Q7
    Related
    ENSP00000356820.4, ENST00000367846.8
    Conserved Domains (1) summary
    pfam03650
    Location:27125
    MPC; Uncharacterized protein family (UPF0041)

RNA

  1. NR_026550.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC104157, Z97876

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    167916675..167937072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711266.4XP_006711329.1  mitochondrial pyruvate carrier 2 isoform X1

    See identical proteins and their annotated locations for XP_006711329.1

    UniProtKB/Swiss-Prot
    A8K261, O95563, Q3SXR6, Q6FIF3
    UniProtKB/TrEMBL
    B2R4Q7
    Related
    ENSP00000392874.1, ENST00000458574.1
    Conserved Domains (1) summary
    pfam03650
    Location:27125
    MPC; Uncharacterized protein family (UPF0041)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    167268139..167288538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335856.1XP_054191831.1  mitochondrial pyruvate carrier 2 isoform X1

    UniProtKB/Swiss-Prot
    A8K261, O95563, Q3SXR6, Q6FIF3
    UniProtKB/TrEMBL
    B2R4Q7