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NEPRO nucleolus and neural progenitor protein [ Homo sapiens (human) ]

Gene ID: 25871, updated on 20-Mar-2020

Summary

Official Symbol
NEPROprovided by HGNC
Official Full Name
nucleolus and neural progenitor proteinprovided by HGNC
Primary source
HGNC:HGNC:24496
See related
Ensembl:ENSG00000163608 MIM:617089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET17; C3orf17
Expression
Ubiquitous expression in thyroid (RPKM 9.6), lymph node (RPKM 9.2) and 25 other tissues See more
Orthologs

Genomic context

See NEPRO in Genome Data Viewer
Location:
3q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (113002444..113019721, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (112721291..112738555, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CD200 receptor 1 Neighboring gene GTP binding protein 8 (putative) Neighboring gene uncharacterized LOC107986114 Neighboring gene endogenous retrovirus group K member 7 Gag polyprotein Neighboring gene VISTA enhancer hs1685

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434F2021

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
nucleolus and neural progenitor protein
Names
protein nepro homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319109.2NP_001306038.1  nucleolus and neural progenitor protein isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two consecutive exons in the coding region compared to variant 1. The encoded isoform (d) is shorter than isoform 1.
    Source sequence(s)
    AC074044, CR749341
    Consensus CDS
    CCDS82820.1
    UniProtKB/Swiss-Prot
    Q6NW34
    Related
    ENSP00000373173.2, ENST00000383675.6
    Conserved Domains (1) summary
    pfam14780
    Location:12118
    DUF4477; Domain of unknown function (DUF4477)
  2. NM_001319110.2NP_001306039.1  nucleolus and neural progenitor protein isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AC074044, AK295954, CR749341
    UniProtKB/Swiss-Prot
    Q6NW34
    UniProtKB/TrEMBL
    B4DJ73
  3. NM_001319111.2NP_001306040.1  nucleolus and neural progenitor protein isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and 5' coding region which results in the use of an alternate start codon and a frameshift compared to variant 1. The encoded isoform (f) is shorter and has a distinct N-terminus compared to isoform a
    Source sequence(s)
    AC074044, AK300811, CR749341
    UniProtKB/Swiss-Prot
    Q6NW34
    UniProtKB/TrEMBL
    B4DUV5
  4. NM_001319112.2NP_001306041.1  nucleolus and neural progenitor protein isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and 5' coding region which results in the use of a downstream start codon compared to variant 1. The encoded isoform (g) is shorter than isoform a.
    Source sequence(s)
    AC074044, AK295165, CR749341
    UniProtKB/Swiss-Prot
    Q6NW34
    UniProtKB/TrEMBL
    B4DHL5
    Conserved Domains (1) summary
    pfam14780
    Location:191
    DUF4477; Domain of unknown function (DUF4477)
  5. NM_001319114.2NP_001306043.1  nucleolus and neural progenitor protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region which results in the use of a downstream start codon compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC074044, AK024325, BC056663, CR749341
    UniProtKB/Swiss-Prot
    Q6NW34
    Conserved Domains (1) summary
    pfam14780
    Location:166
    DUF4477; Domain of unknown function (DUF4477)
  6. NM_001319115.2NP_001306044.1  nucleolus and neural progenitor protein isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region which results in the use of a downstream start codon compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC074044, AL537045, BC056663, BM152568, CR749341
    UniProtKB/Swiss-Prot
    Q6NW34
    Conserved Domains (1) summary
    pfam14780
    Location:1105
    DUF4477; Domain of unknown function (DUF4477)
  7. NM_015412.4NP_056227.2  nucleolus and neural progenitor protein isoform a

    See identical proteins and their annotated locations for NP_056227.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC074044, AL117573, BC056663, BM152568
    Consensus CDS
    CCDS33824.1
    UniProtKB/Swiss-Prot
    Q6NW34
    Related
    ENSP00000320251.5, ENST00000314400.10
    Conserved Domains (1) summary
    pfam14780
    Location:12202
    DUF4477; Domain of unknown function (DUF4477)

RNA

  1. NR_134969.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks multiple exons in the coding region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC074044, AK293218, CR749341

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    113002444..113019721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006102.2XP_016861591.1  nucleolus and neural progenitor protein isoform X2

  2. XM_011512638.2XP_011510940.1  nucleolus and neural progenitor protein isoform X3

    See identical proteins and their annotated locations for XP_011510940.1

  3. XM_011512635.2XP_011510937.1  nucleolus and neural progenitor protein isoform X3

    See identical proteins and their annotated locations for XP_011510937.1

  4. XM_011512636.2XP_011510938.1  nucleolus and neural progenitor protein isoform X3

    See identical proteins and their annotated locations for XP_011510938.1

  5. XM_005247276.2XP_005247333.1  nucleolus and neural progenitor protein isoform X1

    See identical proteins and their annotated locations for XP_005247333.1

    Related
    ENST00000486271.5
    Conserved Domains (1) summary
    pfam14780
    Location:166
    DUF4477; Domain of unknown function (DUF4477)
  6. XM_017006103.1XP_016861592.1  nucleolus and neural progenitor protein isoform X4

RNA

  1. XR_241481.3 RNA Sequence

    Related
    ENST00000472637.5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025072.2: Suppressed sequence

    Description
    NM_001025072.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  2. NM_001025073.2: Suppressed sequence

    Description
    NM_001025073.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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