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BRMS1 BRMS1 transcriptional repressor and anoikis regulator [ Homo sapiens (human) ]

Gene ID: 25855, updated on 13-Mar-2020

Summary

Official Symbol
BRMS1provided by HGNC
Official Full Name
BRMS1 transcriptional repressor and anoikis regulatorprovided by HGNC
Primary source
HGNC:HGNC:17262
See related
Ensembl:ENSG00000174744 MIM:606259
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 18.9), testis (RPKM 16.4) and 25 other tissues See more
Orthologs

Genomic context

See BRMS1 in Genome Data Viewer
Location:
11q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (66337333..66345125, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66104804..66112596, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CD248 molecule Neighboring gene Ras and Rab interactor 1 Neighboring gene uncharacterized LOC102724064 Neighboring gene beta-1,4-glucuronyltransferase 1 Neighboring gene tRNA-Ser (anticodon GCT) 3-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564A063

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NF-kappaB binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
breast cancer metastasis-suppressor 1
Names
breast cancer metastasis suppressor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024957.2NP_001020128.1  breast cancer metastasis-suppressor 1 isoform 2

    See identical proteins and their annotated locations for NP_001020128.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon which results in the use of a downstream stop codon, compared to variant 1. The encoded protein (isoform 2) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AP001107, BM312965, CB130346, CB529276
    Consensus CDS
    CCDS44654.1
    UniProtKB/TrEMBL
    G5E9I4
    Related
    ENSP00000396052.2, ENST00000425825.6
    Conserved Domains (1) summary
    pfam08598
    Location:60177
    Sds3; Sds3-like
  2. NM_015399.4NP_056214.1  breast cancer metastasis-suppressor 1 isoform 1

    See identical proteins and their annotated locations for NP_056214.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest and more abundant transcript and encodes isoform (1).
    Source sequence(s)
    AP001107, BU734281, CB130346
    Consensus CDS
    CCDS8135.1
    UniProtKB/Swiss-Prot
    Q9HCU9
    Related
    ENSP00000353042.3, ENST00000359957.8
    Conserved Domains (1) summary
    pfam08598
    Location:60178
    Sds3; Sds3-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    66337333..66345125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448426.1XP_024304194.1  breast cancer metastasis-suppressor 1 isoform X2

    Conserved Domains (1) summary
    pfam08598
    Location:60178
    Sds3; Sds3-like
  2. XM_024448425.1XP_024304193.1  breast cancer metastasis-suppressor 1 isoform X1

    Related
    ENSP00000431510.1, ENST00000524699.5
    Conserved Domains (1) summary
    pfam08598
    Location:60178
    Sds3; Sds3-like

RNA

  1. XR_002957138.1 RNA Sequence

    Related
    ENST00000530238.5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024958.1: Suppressed sequence

    Description
    NM_001024958.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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