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ANAPC13 anaphase promoting complex subunit 13 [ Homo sapiens (human) ]

Gene ID: 25847, updated on 24-Nov-2020

Summary

Official Symbol
ANAPC13provided by HGNC
Official Full Name
anaphase promoting complex subunit 13provided by HGNC
Primary source
HGNC:HGNC:24540
See related
Ensembl:ENSG00000129055 MIM:614484
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SWM1; APC13
Summary
This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]
Expression
Ubiquitous expression in thyroid (RPKM 36.9), kidney (RPKM 32.9) and 25 other tissues See more
Orthologs

Genomic context

See ANAPC13 in Genome Data Viewer
Location:
3q22.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (134477704..134486023, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (134196546..134204865, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosome binding domain 1 pseudogene Neighboring gene high mobility group box 3 pseudogene 13 Neighboring gene microRNA 4788 Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene centrosomal protein 63 Neighboring gene EPH receptor B1 Neighboring gene kyphoscoliosis peptidase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis identifies 20 loci that influence adult height.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp566D193

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
anaphase-promoting complex subunit 13
Names
cyclosome subunit 13

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242374.1NP_001229303.1  anaphase-promoting complex subunit 13

    See identical proteins and their annotated locations for NP_001229303.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC010207, AK290761, AV682398, BU627217
    Consensus CDS
    CCDS3085.1
    UniProtKB/Swiss-Prot
    Q9BS18
    UniProtKB/TrEMBL
    A8K3Z6
    Related
    ENSP00000421842.1, ENST00000510994.5
    Conserved Domains (1) summary
    pfam05839
    Location:174
    Apc13p; Apc13p protein
  2. NM_001242375.1NP_001229304.1  anaphase-promoting complex subunit 13

    See identical proteins and their annotated locations for NP_001229304.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC010207, AV682398, BU627217, CN258858
    Consensus CDS
    CCDS3085.1
    UniProtKB/Swiss-Prot
    Q9BS18
    UniProtKB/TrEMBL
    A8K3Z6
    Related
    ENSP00000427327.1, ENST00000514612.5
    Conserved Domains (1) summary
    pfam05839
    Location:174
    Apc13p; Apc13p protein
  3. NM_015391.4NP_056206.1  anaphase-promoting complex subunit 13

    See identical proteins and their annotated locations for NP_056206.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK026550, BC005398
    Consensus CDS
    CCDS3085.1
    UniProtKB/Swiss-Prot
    Q9BS18
    UniProtKB/TrEMBL
    A8K3Z6
    Related
    ENSP00000346987.5, ENST00000354910.9
    Conserved Domains (1) summary
    pfam05839
    Location:174
    Apc13p; Apc13p protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    134477704..134486023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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