U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TMT1A thiol methyltransferase 1A [ Homo sapiens (human) ]

Gene ID: 25840, updated on 17-Jun-2024

Summary

Official Symbol
TMT1Aprovided by HGNC
Official Full Name
thiol methyltransferase 1Aprovided by HGNC
Primary source
HGNC:HGNC:24550
See related
Ensembl:ENSG00000185432 MIM:618338; AllianceGenome:HGNC:24550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AAMB; AAM-B; METTL7A
Summary
Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Located in lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver (RPKM 132.2), thyroid (RPKM 109.3) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TMT1A in Genome Data Viewer
Location:
12q13.12
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (50925015..50932508)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (50887081..50895782)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51318798..51326291)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 519, pseudogene Neighboring gene transmembrane serine protease 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51251231-51251732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51251733-51252232 Neighboring gene CRISPRi-validated cis-regulatory element chr12.1615 Neighboring gene MPRA-validated peak1732 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6365 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:51319135-51319678 Neighboring gene Sharpr-MPRA regulatory region 4642 Neighboring gene HIG1 hypoxia inducible domain family member 1C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:51346409-51346909 Neighboring gene solute carrier family 11 member 2 Neighboring gene MPRA-validated peak1733 silencer Neighboring gene RNA, U7 small nuclear 39 pseudogene Neighboring gene RNA, U6 small nuclear 87, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp586A0522

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA m(6)A methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thiol S-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in lncRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in odontogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
thiol S-methyltransferase TMT1A; N6-adenosine-methyltransferase TMT1A
Names
methyltransferase TMT1A
methyltransferase like 7A
methyltransferase-like protein 7A
protein AAM-B
putative methyltransferase-like protein 7A
NP_054752.3
XP_054227679.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014033.4NP_054752.3  thiol S-methyltransferase TMT1A precursor

    See identical proteins and their annotated locations for NP_054752.3

    Status: VALIDATED

    Source sequence(s)
    AC008121, AY358797, BM805242
    Consensus CDS
    CCDS8804.1
    UniProtKB/Swiss-Prot
    Q9H7R3, Q9H8H3, Q9UHZ7, Q9Y422
    UniProtKB/TrEMBL
    H0YI09
    Related
    ENSP00000331787.4, ENST00000332160.5
    Conserved Domains (1) summary
    pfam08241
    Location:75172
    Methyltransf_11; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    50925015..50932508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    50887081..50895782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371704.1XP_054227679.1  N6-adenosine-methyltransferase TMT1A isoform X1

    UniProtKB/Swiss-Prot
    Q9H7R3, Q9H8H3, Q9UHZ7, Q9Y422
    UniProtKB/TrEMBL
    H0YI09