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METTL7A methyltransferase like 7A [ Homo sapiens (human) ]

Gene ID: 25840, updated on 6-Oct-2019

Summary

Official Symbol
METTL7Aprovided by HGNC
Official Full Name
methyltransferase like 7Aprovided by HGNC
Primary source
HGNC:HGNC:24550
See related
Ensembl:ENSG00000185432 MIM:618338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AAMB; AAM-B
Expression
Broad expression in liver (RPKM 132.2), thyroid (RPKM 109.3) and 24 other tissues See more
Orthologs

Genomic context

See METTL7A in Genome Data Viewer
Location:
12q13.12
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (50925015..50932508)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51317780..51326300)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 519, pseudogene Neighboring gene transmembrane serine protease 12 Neighboring gene Sharpr-MPRA regulatory region 4642 Neighboring gene HIG1 hypoxia inducible domain family member 1C Neighboring gene solute carrier family 11 member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp586A0522

Gene Ontology Provided by GOA

Function Evidence Code Pubs
methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
methylation IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
lipid droplet IDA
Inferred from Direct Assay
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
methyltransferase-like protein 7A
Names
protein AAM-B
NP_054752.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014033.4NP_054752.3  methyltransferase-like protein 7A precursor

    See identical proteins and their annotated locations for NP_054752.3

    Status: VALIDATED

    Source sequence(s)
    AC008121, AY358797, BM805242
    Consensus CDS
    CCDS8804.1
    UniProtKB/Swiss-Prot
    Q9H8H3
    UniProtKB/TrEMBL
    A0A024R118
    Related
    ENSP00000331787.4, ENST00000332160.5
    Conserved Domains (1) summary
    pfam08241
    Location:75172
    Methyltransf_11; Methyltransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    50925015..50932508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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