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RAB26 RAB26, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 25837, updated on 8-Jul-2021

Summary

Official Symbol
RAB26provided by HGNC
Official Full Name
RAB26, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:14259
See related
Ensembl:ENSG00000167964 MIM:605455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
V46133
Summary
Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010]
Expression
Broad expression in brain (RPKM 4.5), salivary gland (RPKM 3.5) and 15 other tissues See more
Orthologs
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Genomic context

See RAB26 in Genome Data Viewer
Location:
16p13.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2148144..2154165)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2198145..2204166)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene polycystin 1, transient receptor potential channel interacting Neighboring gene microRNA 3180-5 Neighboring gene microRNA 4516 Neighboring gene small nucleolar RNA, C/D box 60 Neighboring gene small nucleolar RNA host gene 19 Neighboring gene TNF receptor associated factor 7 Neighboring gene CASK interacting protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GMP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in anchored component of synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in anchored component of synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in anchored component of synaptic vesicle membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in anchored component of synaptic vesicle membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intrinsic component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in secretory granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ras-related protein Rab-26
Names
Ras-related oncogene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308053.1NP_001294982.1  ras-related protein Rab-26 isoform 2

    See identical proteins and their annotated locations for NP_001294982.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AB027137, AC009065, AK314110
    Consensus CDS
    CCDS76806.1
    UniProtKB/Swiss-Prot
    Q9ULW5
    Related
    ENSP00000441580.1, ENST00000541451.5
    Conserved Domains (1) summary
    cd04112
    Location:1188
    Rab26; Rab GTPase family 26 (Rab26)
  2. NM_014353.5NP_055168.2  ras-related protein Rab-26 isoform 1

    See identical proteins and their annotated locations for NP_055168.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC009065
    Consensus CDS
    CCDS10460.1
    UniProtKB/Swiss-Prot
    Q9ULW5
    Related
    ENSP00000210187.6, ENST00000210187.11
    Conserved Domains (1) summary
    cd04112
    Location:64254
    Rab26; Rab GTPase family 26 (Rab26)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2148144..2154165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522448.1XP_011520750.1  ras-related protein Rab-26 isoform X1

    Related
    ENST00000562735.5
    Conserved Domains (2) summary
    smart00175
    Location:64197
    RAB; Rab subfamily of small GTPases
    cl21455
    Location:64197
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_011522450.2XP_011520752.1  ras-related protein Rab-26 isoform X2

    Conserved Domains (1) summary
    cl21455
    Location:1138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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