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MGAT4C MGAT4 family member C [ Homo sapiens (human) ]

Gene ID: 25834, updated on 21-Dec-2019

Summary

Official Symbol
MGAT4Cprovided by HGNC
Official Full Name
MGAT4 family member Cprovided by HGNC
Primary source
HGNC:HGNC:30871
See related
Ensembl:ENSG00000182050 MIM:607385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GNTIVH; HGNT-IV-H
Expression
Biased expression in thyroid (RPKM 3.6), brain (RPKM 1.8) and 3 other tissues See more
Orthologs

Genomic context

See MGAT4C in Genome Data Viewer
Location:
12q21.31-q21.32
Exon count:
19
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (85955667..86839000, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (86373037..87232681, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Ras association domain family member 9 Neighboring gene neurotensin Neighboring gene uncharacterized LOC105369877 Neighboring gene microRNA 3059 Neighboring gene uncharacterized LOC105369878 Neighboring gene ribosomal protein L23a pseudogene 68 Neighboring gene uncharacterized LOC105369879

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed
Envelope transmembrane glycoprotein gp41 env Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
Names
N-acetylglucosaminyltransferase IV homolog
N-acetylglucosaminyltransferase IVc
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc
UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc
UDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV
UDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homolog
glcNAc-T IVc
gnT-IVc
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
NP_001338211.1
NP_001338212.1
NP_001338213.1
NP_001338214.1
NP_001338215.1
NP_001338216.1
NP_001338217.1
NP_001338218.1
NP_001338220.1
NP_037376.2
XP_011536453.1
XP_016874632.1
XP_016874633.1
XP_016874635.1
XP_024304698.1
XP_024304699.1
XP_024304700.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351282.2NP_001338211.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC016993, AC079865, AC139663, AC139697, KF511187
    Conserved Domains (1) summary
    pfam04666
    Location:102368
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  2. NM_001351283.2NP_001338212.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variant 3, encodes isoform b.
    Source sequence(s)
    AC016993, AC079865, AC139663, AC139697, KF511187
    Conserved Domains (1) summary
    pfam04666
    Location:93359
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  3. NM_001351284.2NP_001338213.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 2, encodes isoform b.
    Source sequence(s)
    AC016993, AC139697, DA149452, DA710239, DC371656, KF511187
    Conserved Domains (1) summary
    pfam04666
    Location:93359
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  4. NM_001351285.2NP_001338214.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 4 and 6-10, encodes isoform c.
    Source sequence(s)
    AC010196, AC016993, AC079596, AC079865, AC087887, AC139663, AC139697, KF511187
    Consensus CDS
    CCDS9030.1
    Conserved Domains (1) summary
    pfam04666
    Location:64330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  5. NM_001351286.2NP_001338215.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 4, 5, and 7-10, encodes isoform c.
    Source sequence(s)
    AC010196, AC016993, AC079596, AC079865, AC087887, AC139663, AC139697, KF511187
    Consensus CDS
    CCDS9030.1
    Related
    ENSP00000478300.1, ENST00000621808.4
    Conserved Domains (1) summary
    pfam04666
    Location:64330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  6. NM_001351287.2NP_001338216.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 4-6 and 8-10, encodes isoform c.
    Source sequence(s)
    AC016993, AC079865, AC139663, AC139697, KF511187
    Consensus CDS
    CCDS9030.1
    Related
    ENSP00000481096.1, ENST00000611864.4
    Conserved Domains (1) summary
    pfam04666
    Location:64330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  7. NM_001351288.2NP_001338217.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 4-7, 9, and 10, encodes isoform c.
    Source sequence(s)
    AC016993, AC079865, AC139663, AC139697, KF511187
    Consensus CDS
    CCDS9030.1
    Related
    ENSP00000446647.1, ENST00000552808.6
    Conserved Domains (1) summary
    pfam04666
    Location:64330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  8. NM_001351289.2NP_001338218.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 4-8 and 10, encodes isoform c.
    Source sequence(s)
    AC016993, AC139697, BC026068, DA149452, DA710239, KF511187
    Consensus CDS
    CCDS9030.1
    Related
    ENSP00000449172.1, ENST00000547225.5
    Conserved Domains (1) summary
    pfam04666
    Location:64330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  9. NM_001351291.2NP_001338220.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 4-9, encodes isoform c.
    Source sequence(s)
    AC016993, AC139697, AK127727, DA149452, DA710239, KF511187
    Consensus CDS
    CCDS9030.1
    Related
    ENSP00000477650.1, ENST00000620241.4
    Conserved Domains (1) summary
    pfam04666
    Location:64330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  10. NM_013244.5NP_037376.2  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform c

    See identical proteins and their annotated locations for NP_037376.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 5-10, encodes isoform c.
    Source sequence(s)
    AC016993, AC139697, BC035851, BX954189, DA489647, KF511187
    Consensus CDS
    CCDS9030.1
    UniProtKB/Swiss-Prot
    Q9UBM8
    Conserved Domains (1) summary
    pfam04666
    Location:64330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

RNA

  1. NR_147093.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016993, AC139697, DA149452, DA710239, KF511187

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    85955667..86839000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448930.1XP_024304698.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

    Conserved Domains (1) summary
    pfam04666
    Location:138404
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  2. XM_011538151.3XP_011536453.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X3

    See identical proteins and their annotated locations for XP_011536453.1

    Conserved Domains (1) summary
    pfam04666
    Location:102368
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  3. XM_017019146.2XP_016874635.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X4

    UniProtKB/Swiss-Prot
    Q9UBM8
    Conserved Domains (1) summary
    pfam04666
    Location:93359
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  4. XM_024448931.1XP_024304699.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X3

    Conserved Domains (1) summary
    pfam04666
    Location:102368
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  5. XM_024448932.1XP_024304700.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X5

    Conserved Domains (1) summary
    pfam04666
    Location:67333
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  6. XM_017019144.2XP_016874633.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X3

    Conserved Domains (1) summary
    pfam04666
    Location:102368
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
  7. XM_017019143.2XP_016874632.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X2

    Conserved Domains (1) summary
    pfam04666
    Location:113379
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
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