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HECTD1 HECT domain E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

Gene ID: 25831, updated on 4-Dec-2022

Summary

Official Symbol
HECTD1provided by HGNC
Official Full Name
HECT domain E3 ubiquitin protein ligase 1provided by HGNC
Primary source
HGNC:HGNC:20157
See related
Ensembl:ENSG00000092148 MIM:618649; AllianceGenome:HGNC:20157
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EULIR
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in anatomical structure development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein K63-linked ubiquitination. Predicted to act upstream of or within several processes, including animal organ development; negative regulation of protein localization to plasma membrane; and protein autoubiquitination. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 22.9), testis (RPKM 20.1) and 25 other tissues See more
Orthologs
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Genomic context

See HECTD1 in Genome Data Viewer
Location:
14q12
Exon count:
45
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (31100117..31207793, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (25297934..25405631, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (31569323..31676999, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene striatin 3 Neighboring gene intraflagellar transport 20 homolog (Chlamydomonas) pseudogene Neighboring gene adaptor related protein complex 4 subunit sigma 1 Neighboring gene ribosomal protein L21 pseudogene 5 Neighboring gene RNA, U6 small nuclear 541, pseudogene Neighboring gene Sharpr-MPRA regulatory region 11779 Neighboring gene asparaginyl-tRNA synthetase 1 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38315, KIAA1131

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within aorta development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within heart valve development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in natural killer cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in neural tube closure IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein autoubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in trophoblast giant cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ventricular septum development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase HECTD1
Names
E3 ligase for inhibin receptor
HECT domain containing E3 ubiquitin protein ligase 1
HECT domain-containing protein 1
HECT-type E3 ubiquitin transferase HECTD1
NP_056197.3
XP_005267559.2
XP_011534921.1
XP_011534923.1
XP_011534924.1
XP_016876637.1
XP_016876638.1
XP_016876640.1
XP_016876641.1
XP_016876642.1
XP_024305294.1
XP_024305295.1
XP_047287156.1
XP_047287157.1
XP_047287158.1
XP_047287159.1
XP_047287160.1
XP_047287161.1
XP_047287162.1
XP_047287163.1
XP_047287164.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411010.1NP_001397939.1  E3 ubiquitin-protein ligase HECTD1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL121808, AL136418, KC877516
    Consensus CDS
    CCDS91860.1
    UniProtKB/TrEMBL
    A0A8I5QJU2
  2. NM_015382.4NP_056197.3  E3 ubiquitin-protein ligase HECTD1

    See identical proteins and their annotated locations for NP_056197.3

    Status: VALIDATED

    Source sequence(s)
    AB032957, AL136418, AY254380, BM977042, DA440215, DA509926, DA818448
    Consensus CDS
    CCDS41939.1
    UniProtKB/Swiss-Prot
    Q9UFZ7, Q9ULT8
    Related
    ENSP00000382269.1, ENST00000399332.6
    Conserved Domains (6) summary
    cd00078
    Location:21312608
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:12771335
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:11071240
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam12796
    Location:366457
    Ank_2; Ankyrin repeats (3 copies)
    pfam18410
    Location:18921965
    BTHB; Basic tilted helix bundle domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    31100117..31207793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021153.2XP_016876642.1  E3 ubiquitin-protein ligase HECTD1 isoform X10

    UniProtKB/TrEMBL
    H0YJD4
    Related
    ENSP00000451260.2, ENST00000554882.6
  2. XM_047431208.1XP_047287164.1  E3 ubiquitin-protein ligase HECTD1 isoform X11

  3. XM_011536621.3XP_011534923.1  E3 ubiquitin-protein ligase HECTD1 isoform X9

    See identical proteins and their annotated locations for XP_011534923.1

    Conserved Domains (6) summary
    cd00078
    Location:18522329
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:12771302
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:11071240
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam12796
    Location:366457
    Ank_2; Ankyrin repeats (3 copies)
    pfam18410
    Location:16131686
    BTHB; Basic tilted helix bundle domain
  4. XM_047431201.1XP_047287157.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

  5. XM_047431206.1XP_047287162.1  E3 ubiquitin-protein ligase HECTD1 isoform X7

  6. XM_047431200.1XP_047287156.1  E3 ubiquitin-protein ligase HECTD1 isoform X3

    Related
    ENSP00000510470.1, ENST00000692835.1
  7. XM_047431204.1XP_047287160.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

  8. XM_011536619.3XP_011534921.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

    See identical proteins and their annotated locations for XP_011534921.1

    UniProtKB/TrEMBL
    A0A087X2H1
    Conserved Domains (6) summary
    cd00078
    Location:21292606
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:12771335
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:11071240
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam12796
    Location:366457
    Ank_2; Ankyrin repeats (3 copies)
    pfam18410
    Location:18901963
    BTHB; Basic tilted helix bundle domain
  9. XM_047431202.1XP_047287158.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

  10. XM_005267502.4XP_005267559.2  E3 ubiquitin-protein ligase HECTD1 isoform X1

    See identical proteins and their annotated locations for XP_005267559.2

    UniProtKB/Swiss-Prot
    Q9UFZ7, Q9ULT8
    Related
    ENSP00000450697.1, ENST00000553700.5
    Conserved Domains (6) summary
    cd00078
    Location:21312608
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:12771335
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:11071240
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam12796
    Location:366457
    Ank_2; Ankyrin repeats (3 copies)
    pfam18410
    Location:18921965
    BTHB; Basic tilted helix bundle domain
  11. XM_017021152.3XP_016876641.1  E3 ubiquitin-protein ligase HECTD1 isoform X10

    UniProtKB/TrEMBL
    H0YJD4
  12. XM_017021151.3XP_016876640.1  E3 ubiquitin-protein ligase HECTD1 isoform X9

    Related
    ENSP00000508604.1, ENST00000691390.1
    Conserved Domains (6) summary
    cd00078
    Location:18522329
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:12771302
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:11071240
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam12796
    Location:366457
    Ank_2; Ankyrin repeats (3 copies)
    pfam18410
    Location:16131686
    BTHB; Basic tilted helix bundle domain
  13. XM_047431207.1XP_047287163.1  E3 ubiquitin-protein ligase HECTD1 isoform X8

  14. XM_017021149.3XP_016876638.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

    Conserved Domains (6) summary
    cd00078
    Location:20822559
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:12771321
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:11071240
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam12796
    Location:366457
    Ank_2; Ankyrin repeats (3 copies)
    pfam18410
    Location:18431916
    BTHB; Basic tilted helix bundle domain
  15. XM_047431205.1XP_047287161.1  E3 ubiquitin-protein ligase HECTD1 isoform X7

  16. XM_017021148.3XP_016876637.1  E3 ubiquitin-protein ligase HECTD1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5QJU2
    Conserved Domains (6) summary
    cd00078
    Location:20842561
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:12771321
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:11071240
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam12796
    Location:366457
    Ank_2; Ankyrin repeats (3 copies)
    pfam18410
    Location:18451918
    BTHB; Basic tilted helix bundle domain
  17. XM_047431203.1XP_047287159.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

  18. XM_024449526.2XP_024305294.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

    UniProtKB/TrEMBL
    A0A087X2H1
    Related
    ENSP00000484981.2, ENST00000611816.5
    Conserved Domains (6) summary
    cd00078
    Location:21292606
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:12771335
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:11071240
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam12796
    Location:366457
    Ank_2; Ankyrin repeats (3 copies)
    pfam18410
    Location:18901963
    BTHB; Basic tilted helix bundle domain
  19. XM_024449527.2XP_024305295.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

    Conserved Domains (5) summary
    cd00078
    Location:20702547
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:12771335
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:11071240
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam12796
    Location:366457
    Ank_2; Ankyrin repeats (3 copies)
  20. XM_011536622.2XP_011534924.1  E3 ubiquitin-protein ligase HECTD1 isoform X12

    Conserved Domains (4) summary
    smart00119
    Location:16052057
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:15812058
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam06701
    Location:727785
    MIB_HERC2; Mib_herc2
    cl23730
    Location:557690
    F5_F8_type_C; F5/8 type C domain

RNA

  1. XR_001750215.3 RNA Sequence

    Related
    ENST00000687002.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    25297934..25405631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)