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HECTD1 HECT domain E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

Gene ID: 25831, updated on 5-Jan-2020

Summary

Official Symbol
HECTD1provided by HGNC
Official Full Name
HECT domain E3 ubiquitin protein ligase 1provided by HGNC
Primary source
HGNC:HGNC:20157
See related
Ensembl:ENSG00000092148 MIM:618649
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EULIR
Expression
Ubiquitous expression in thyroid (RPKM 22.9), testis (RPKM 20.1) and 25 other tissues See more
Orthologs

Genomic context

See HECTD1 in Genome Data Viewer
Location:
14q12
Exon count:
45
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (31100117..31207793, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (31569323..31677266, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene striatin 3 Neighboring gene intraflagellar transport 20 homolog (Chlamydomonas) pseudogene Neighboring gene adaptor related protein complex 4 subunit sigma 1 Neighboring gene ribosomal protein L21 pseudogene 5 Neighboring gene RNA, U6 small nuclear 541, pseudogene Neighboring gene Sharpr-MPRA regulatory region 11779 Neighboring gene uncharacterized LOC105370436

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38315, KIAA1131

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aorta development ISS
Inferred from Sequence or Structural Similarity
more info
 
heart valve development ISS
Inferred from Sequence or Structural Similarity
more info
 
protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ventricular septum development ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase HECTD1
Names
E3 ligase for inhibin receptor
HECT domain containing E3 ubiquitin protein ligase 1
HECT domain-containing protein 1
HECT-type E3 ubiquitin transferase HECTD1
NP_056197.3
XP_005267559.2
XP_011534921.1
XP_011534923.1
XP_011534924.1
XP_016876637.1
XP_016876638.1
XP_016876640.1
XP_016876641.1
XP_016876642.1
XP_024305294.1
XP_024305295.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015382.4NP_056197.3  E3 ubiquitin-protein ligase HECTD1

    See identical proteins and their annotated locations for NP_056197.3

    Status: VALIDATED

    Source sequence(s)
    AB032957, AL136418, AY254380, BM977042, DA440215, DA509926, DA818448
    Consensus CDS
    CCDS41939.1
    UniProtKB/Swiss-Prot
    Q9ULT8
    Related
    ENSP00000382269.1, ENST00000399332.6
    Conserved Domains (5) summary
    cd00078
    Location:21312608
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:12771335
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:11071240
    Sad1_UNC; Sad1 / UNC-like C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    31100117..31207793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267502.3XP_005267559.2  E3 ubiquitin-protein ligase HECTD1 isoform X1

    See identical proteins and their annotated locations for XP_005267559.2

    UniProtKB/Swiss-Prot
    Q9ULT8
    Related
    ENSP00000450697.1, ENST00000553700.5
    Conserved Domains (5) summary
    cd00078
    Location:21312608
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:12771335
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:11071240
    Sad1_UNC; Sad1 / UNC-like C-terminal
  2. XM_017021152.2XP_016876641.1  E3 ubiquitin-protein ligase HECTD1 isoform X7

  3. XM_017021151.2XP_016876640.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

    Conserved Domains (7) summary
    smart00119
    Location:18762328
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:18522329
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06701
    Location:12771302
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:366457
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    cl23730
    Location:11071240
    F5_F8_type_C; F5/8 type C domain
  4. XM_024449526.1XP_024305294.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

    Related
    ENSP00000484981.1, ENST00000611816.4
    Conserved Domains (5) summary
    cd00078
    Location:21292606
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:12771335
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:11071240
    Sad1_UNC; Sad1 / UNC-like C-terminal
  5. XM_017021153.1XP_016876642.1  E3 ubiquitin-protein ligase HECTD1 isoform X7

  6. XM_011536621.2XP_011534923.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

    See identical proteins and their annotated locations for XP_011534923.1

    Conserved Domains (7) summary
    smart00119
    Location:18762328
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:18522329
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06701
    Location:12771302
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:366457
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    cl23730
    Location:11071240
    F5_F8_type_C; F5/8 type C domain
  7. XM_011536619.2XP_011534921.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

    See identical proteins and their annotated locations for XP_011534921.1

    Conserved Domains (5) summary
    cd00078
    Location:21292606
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:12771335
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:11071240
    Sad1_UNC; Sad1 / UNC-like C-terminal
  8. XM_017021149.2XP_016876638.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

    Conserved Domains (5) summary
    cd00078
    Location:20822559
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:12771321
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:11071240
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam12796
    Location:366457
    Ank_2; Ankyrin repeats (3 copies)
  9. XM_017021148.2XP_016876637.1  E3 ubiquitin-protein ligase HECTD1 isoform X3

    Conserved Domains (5) summary
    cd00078
    Location:20842561
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:12771321
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:11071240
    Sad1_UNC; Sad1 / UNC-like C-terminal
  10. XM_024449527.1XP_024305295.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

    Conserved Domains (5) summary
    cd00078
    Location:20702547
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:396426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:12771335
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:11071240
    Sad1_UNC; Sad1 / UNC-like C-terminal
  11. XM_011536622.1XP_011534924.1  E3 ubiquitin-protein ligase HECTD1 isoform X8

    Conserved Domains (4) summary
    smart00119
    Location:16052057
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:15812058
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam06701
    Location:727785
    MIB_HERC2; Mib_herc2
    cl23730
    Location:557690
    F5_F8_type_C; F5/8 type C domain

RNA

  1. XR_001750214.2 RNA Sequence

  2. XR_001750215.2 RNA Sequence

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