U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SULT4A1 sulfotransferase family 4A member 1 [ Homo sapiens (human) ]

Gene ID: 25830, updated on 3-Dec-2024

Summary

Official Symbol
SULT4A1provided by HGNC
Official Full Name
sulfotransferase family 4A member 1provided by HGNC
Primary source
HGNC:HGNC:14903
See related
Ensembl:ENSG00000130540 MIM:608359; AllianceGenome:HGNC:14903
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NST; BRSTL1; SULTX3; BR-STL-1; DJ388M5.3; hBR-STL-1
Summary
This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 30.9), duodenum (RPKM 4.1) and 2 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SULT4A1 in Genome Data Viewer
Location:
22q13.31
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (43824509..43862513, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (44307367..44345097, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (44220389..44258393, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:44207707-44207948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19191 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44208791-44209592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44215896-44216537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44223866-44224628 Neighboring gene EFCAB6 divergent transcript Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44240991-44241816 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44247635-44248134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44256209-44256708 Neighboring gene Sharpr-MPRA regulatory region 15126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44279103-44279833 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:44293320-44294519 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44301043-44301543 Neighboring gene patatin like phospholipase domain containing 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:44317583-44318083 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:44319500-44320244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:44320245-44320987 Neighboring gene Sharpr-MPRA regulatory region 5125 Neighboring gene patatin like phospholipase domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC40032

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sulfotransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in dendrite arborization IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sulfotransferase 4A1
Names
ST4A1
brain sulfotransferase-like protein
hBR-STL
nervous system cytosolic sulfotransferase
nervous system sulfotransferase
sulfotransferase-related protein
NP_055166.1
XP_011528422.1
XP_011528423.1
XP_047297277.1
XP_047297278.1
XP_054181480.1
XP_054181481.1
XP_054181482.1
XP_054181483.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014351.4NP_055166.1  sulfotransferase 4A1

    See identical proteins and their annotated locations for NP_055166.1

    Status: REVIEWED

    Source sequence(s)
    AF251263, Z97055
    Consensus CDS
    CCDS14051.1
    UniProtKB/Swiss-Prot
    B2R7N3, O43728, Q9BR01
    UniProtKB/TrEMBL
    B7Z320
    Related
    ENSP00000332565.4, ENST00000330884.9
    Conserved Domains (1) summary
    pfam00685
    Location:45277
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    43824509..43862513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530121.2XP_011528423.1  sulfotransferase 4A1 isoform X2

    See identical proteins and their annotated locations for XP_011528423.1

    UniProtKB/TrEMBL
    B7Z2E1
    Conserved Domains (1) summary
    cl21551
    Location:59164
    Sulfotransfer_1; Sulfotransferase domain
  2. XM_047441322.1XP_047297278.1  sulfotransferase 4A1 isoform X4

  3. XM_047441321.1XP_047297277.1  sulfotransferase 4A1 isoform X1

    UniProtKB/TrEMBL
    B7Z320
    Related
    ENSP00000388285.1, ENST00000422525.1
  4. XM_011530120.4XP_011528422.1  sulfotransferase 4A1 isoform X3

    Conserved Domains (1) summary
    pfam00685
    Location:45167
    Sulfotransfer_1; Sulfotransferase domain

RNA

  1. XR_937839.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    44307367..44345097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325506.1XP_054181481.1  sulfotransferase 4A1 isoform X2

    UniProtKB/TrEMBL
    B7Z2E1
  2. XM_054325508.1XP_054181483.1  sulfotransferase 4A1 isoform X4

  3. XM_054325505.1XP_054181480.1  sulfotransferase 4A1 isoform X1

    UniProtKB/TrEMBL
    B7Z320
  4. XM_054325507.1XP_054181482.1  sulfotransferase 4A1 isoform X3

RNA

  1. XR_008485384.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_176874.1: Suppressed sequence

    Description
    NM_176874.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.