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SULT4A1 sulfotransferase family 4A member 1 [ Homo sapiens (human) ]

Gene ID: 25830, updated on 12-Aug-2022

Summary

Official Symbol
SULT4A1provided by HGNC
Official Full Name
sulfotransferase family 4A member 1provided by HGNC
Primary source
HGNC:HGNC:14903
See related
Ensembl:ENSG00000130540 MIM:608359; AllianceGenome:HGNC:14903
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NST; BRSTL1; SULTX3; BR-STL-1; DJ388M5.3; hBR-STL-1
Summary
This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 30.9), duodenum (RPKM 4.1) and 2 other tissues See more
Orthologs
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Genomic context

See SULT4A1 in Genome Data Viewer
Location:
22q13.31
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (43824509..43862513, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (44307367..44345097, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (44220389..44258393, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 6 Neighboring gene ribosomal protein L4 pseudogene Neighboring gene uncharacterized LOC105373058 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 9 Neighboring gene Sharpr-MPRA regulatory region 15126 Neighboring gene patatin like phospholipase domain containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC40032

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sulfotransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in dendrite arborization IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sulfotransferase 4A1
Names
ST4A1
brain sulfotransferase-like protein
hBR-STL
nervous system cytosolic sulfotransferase
nervous system sulfotransferase
sulfotransferase-related protein
NP_055166.1
XP_011528422.1
XP_011528423.1
XP_047297277.1
XP_047297278.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014351.4NP_055166.1  sulfotransferase 4A1

    See identical proteins and their annotated locations for NP_055166.1

    Status: REVIEWED

    Source sequence(s)
    AF251263, Z97055
    Consensus CDS
    CCDS14051.1
    UniProtKB/Swiss-Prot
    O43728, Q9BR01
    Related
    ENSP00000332565.4, ENST00000330884.9
    Conserved Domains (1) summary
    pfam00685
    Location:45277
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    43824509..43862513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530121.2XP_011528423.1  sulfotransferase 4A1 isoform X2

    See identical proteins and their annotated locations for XP_011528423.1

    UniProtKB/TrEMBL
    B7Z2E1
    Conserved Domains (1) summary
    cl21551
    Location:59164
    Sulfotransfer_1; Sulfotransferase domain
  2. XM_047441322.1XP_047297278.1  sulfotransferase 4A1 isoform X4

  3. XM_047441321.1XP_047297277.1  sulfotransferase 4A1 isoform X1

    UniProtKB/TrEMBL
    A0A024R4X9
    Related
    ENSP00000388285.1, ENST00000422525.1
  4. XM_011530120.4XP_011528422.1  sulfotransferase 4A1 isoform X3

    Conserved Domains (1) summary
    pfam00685
    Location:45167
    Sulfotransfer_1; Sulfotransferase domain

RNA

  1. XR_937839.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    44307367..44345097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_176874.1: Suppressed sequence

    Description
    NM_176874.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.