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TXN2 thioredoxin 2 [ Homo sapiens (human) ]

Gene ID: 25828, updated on 24-Nov-2020

Summary

Official Symbol
TXN2provided by HGNC
Official Full Name
thioredoxin 2provided by HGNC
Primary source
HGNC:HGNC:17772
See related
Ensembl:ENSG00000100348 MIM:609063
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TXN; MTRX; TRX2; MT-TRX; COXPD29
Summary
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 39.7), kidney (RPKM 28.5) and 25 other tissues See more
Orthologs

Genomic context

See TXN2 in Genome Data Viewer
Location:
22q12.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (36467036..36481672, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (36863083..36878072, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15a pseudogene 38 Neighboring gene uncharacterized LOC105373018 Neighboring gene FAD dependent oxidoreductase domain containing 2 Neighboring gene uncharacterized LOC105373020 Neighboring gene uncharacterized LOC105373019

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptide-methionine (R)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
 
peptide-methionine (S)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein disulfide oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
glycerol ether metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to axon injury IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to glucose IEA
Inferred from Electronic Annotation
more info
 
response to hormone IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
sulfur amino acid catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
dendrite IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
thioredoxin, mitochondrial
Names
mitochondrial thioredoxin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046718.1 RefSeqGene

    Range
    5001..19595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012473.4NP_036605.2  thioredoxin, mitochondrial precursor

    See identical proteins and their annotated locations for NP_036605.2

    Status: REVIEWED

    Source sequence(s)
    AL022313
    Consensus CDS
    CCDS13928.1
    UniProtKB/Swiss-Prot
    Q99757
    Related
    ENSP00000216185.2, ENST00000216185.7
    Conserved Domains (1) summary
    cd02947
    Location:72162
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    36467036..36481672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530111.3XP_011528413.1  thioredoxin, mitochondrial isoform X3

  2. XM_006724226.1XP_006724289.1  thioredoxin, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006724289.1

    UniProtKB/Swiss-Prot
    Q99757
    Related
    ENSP00000385393.1, ENST00000403313.5
    Conserved Domains (1) summary
    cd02947
    Location:72162
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
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