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TPSG1 tryptase gamma 1 [ Homo sapiens (human) ]

Gene ID: 25823, updated on 17-Jun-2024


Official Symbol
TPSG1provided by HGNC
Official Full Name
tryptase gamma 1provided by HGNC
Primary source
See related
Ensembl:ENSG00000116176 MIM:609341; AllianceGenome:HGNC:14134
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMT; trpA; PRSS31
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
Broad expression in colon (RPKM 7.2), endometrium (RPKM 6.9) and 18 other tissues See more
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Genomic context

See TPSG1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1221651..1225268, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1236961..1240578, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1271651..1275268, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1208711-1209430 Neighboring gene calcium voltage-gated channel subunit alpha1 H Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1213358-1213914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1222787-1223288 Neighboring gene MS205 minisatellite repeat instability region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1248019-1248578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1248579-1249136 Neighboring gene uncharacterized LOC124903623 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1274120-1274306 Neighboring gene uncharacterized LOC124903621 Neighboring gene tryptase beta 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1288568-1289150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1289151-1289731 Neighboring gene tryptase alpha/beta 1

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
enables serine-type peptidase activity TAS
Traceable Author Statement
more info
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
located_in plasma membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
tryptase gamma
serine protease 31
transmembrane tryptase
tryptase gamma I
tryptase gamma II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012467.4NP_036599.4  tryptase gamma preproprotein

    Status: REVIEWED

    Source sequence(s)
    Consensus CDS
    Q96RZ8, Q9C015, Q9NRQ8, Q9NRR2, Q9UBB2
    ENSP00000234798.4, ENST00000234798.5
    Conserved Domains (1) summary
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    1221651..1225268 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060940.1 Alternate T2T-CHM13v2.0

    1236961..1240578 complement
    GenBank, FASTA, Sequence Viewer (Graphics)