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NOCT nocturnin [ Homo sapiens (human) ]

Gene ID: 25819, updated on 5-Aug-2018

Summary

Official Symbol
NOCTprovided by HGNC
Official Full Name
nocturninprovided by HGNC
Primary source
HGNC:HGNC:14254
See related
Ensembl:ENSG00000151014 MIM:608468; Vega:OTTHUMG00000161271
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOC; CCR4L; Ccr4c; CCRN4L
Summary
The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 15.3), liver (RPKM 6.4) and 18 other tissues See more
Orthologs

Genomic context

See NOCT in Genome Data Viewer
Location:
4q31.1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (139015759..139045939)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (139936913..139967093)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene GATA motif-containing MPRA enhancer 163 Neighboring gene uncharacterized LOC105377448 Neighboring gene RNA, U6 small nuclear 531, pseudogene Neighboring gene E74 like ETS transcription factor 2 Neighboring gene RNA, 7SL, cytoplasmic 382, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystem (from REACTOME)
    BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et...
  • Circadian Clock, organism-specific biosystem (from REACTOME)
    Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC78549, MGC142054, MGC142060, MGC4120817

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A)-specific ribonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, exonucleolytic IEA
Inferred from Electronic Annotation
more info
 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian rhythm TAS
Traceable Author Statement
more info
 
cytoplasmic mRNA processing body assembly IEA
Inferred from Electronic Annotation
more info
 
deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to extracellular stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
P-body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
nocturnin
Names
CCR4 carbon catabolite repression 4-like
CCR4 protein homolog
CCR4-like (carbon catabolite repression 4, S.cerevisiae)
carbon catabolite repression 4-like protein
circadian deadenylase NOC
NP_036250.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012118.3NP_036250.2  nocturnin

    See identical proteins and their annotated locations for NP_036250.2

    Status: REVIEWED

    Source sequence(s)
    AC093602, BC113494, HY067201
    Consensus CDS
    CCDS3743.1
    UniProtKB/Swiss-Prot
    Q9UK39
    Related
    ENSP00000280614.2, OTTHUMP00000164538, ENST00000280614.3, OTTHUMT00000257231
    Conserved Domains (1) summary
    cd09096
    Location:144423
    Deadenylase_nocturnin; C-terminal deadenylase domain of nocturnin and related domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    139015759..139045939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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