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TAFA5 TAFA chemokine like family member 5 [ Homo sapiens (human) ]

Gene ID: 25817, updated on 1-Jun-2020

Summary

Official Symbol
TAFA5provided by HGNC
Official Full Name
TAFA chemokine like family member 5provided by HGNC
Primary source
HGNC:HGNC:21592
See related
Ensembl:ENSG00000219438 MIM:617499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAFA-5; FAM19A5; UNQ5208; QLLK5208
Summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Sep 2013]
Expression
Biased expression in brain (RPKM 13.2), endometrium (RPKM 3.4) and 8 other tissues See more
Orthologs

Genomic context

See TAFA5 in Genome Data Viewer
Location:
22q13.32
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (48489553..48751932)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (48885288..49147744)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373080 Neighboring gene uncharacterized LOC105373081 Neighboring gene uncharacterized LOC105373083 Neighboring gene uncharacterized LOC284933 Neighboring gene Sharpr-MPRA regulatory region 11110 Neighboring gene microRNA 4535 Neighboring gene long intergenic non-protein coding RNA 1310

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.
NHGRI GWA Catalog
Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
chemokine-like protein TAFA-5
Names
TAFA protein 5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
family with sequence similarity 19 member A5, C-C motif chemokine like
protein FAM19A5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082967.3NP_001076436.1  chemokine-like protein TAFA-5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001076436.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF131851, DB541899, Z83837
    Consensus CDS
    CCDS46728.1
    UniProtKB/Swiss-Prot
    Q7Z5A7
    Related
    ENSP00000383933.1, ENST00000402357.5
    Conserved Domains (1) summary
    pfam12020
    Location:42130
    TAFA; TAFA family
  2. NM_015381.7NP_056196.2  chemokine-like protein TAFA-5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_056196.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK125256, DB541899, Z83837
    Consensus CDS
    CCDS46729.1
    UniProtKB/Swiss-Prot
    Q7Z5A7
    Related
    ENSP00000351043.5, ENST00000358295.9
    Conserved Domains (1) summary
    pfam12020
    Location:35123
    TAFA; TAFA family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    48489553..48751932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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