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TNFAIP8 TNF alpha induced protein 8 [ Homo sapiens (human) ]

Gene ID: 25816, updated on 9-Oct-2022

Summary

Official Symbol
TNFAIP8provided by HGNC
Official Full Name
TNF alpha induced protein 8provided by HGNC
Primary source
HGNC:HGNC:17260
See related
Ensembl:ENSG00000145779 MIM:612111; AllianceGenome:HGNC:17260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13
Summary
Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in positive regulation of apoptotic process. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lymph node (RPKM 31.1), fat (RPKM 24.0) and 19 other tissues See more
Orthologs
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Genomic context

See TNFAIP8 in Genome Data Viewer
Location:
5q23.1
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (119268759..119399688)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (119789607..119920525)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (118604454..118735383)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Dmx like 1 Neighboring gene RNA, U6 small nuclear 701, pseudogene Neighboring gene microRNA 5706 Neighboring gene RNA, 7SL, cytoplasmic 174, pseudogene Neighboring gene uncharacterized LOC102723444 Neighboring gene Sharpr-MPRA regulatory region 6110 Neighboring gene Sharpr-MPRA regulatory region 10011 Neighboring gene RNA, 5S ribosomal pseudogene 190

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of tumor necrosis factor, alpha-induced protein 8 (TNFAIP8) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tumor necrosis factor alpha-induced protein 8
Names
NF-kappa-B-inducible DED-containing protein
TNF-induced protein GG2-1
head and neck tumor and metastasis-related protein
tumor necrosis factor, alpha induced protein 8

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077654.3NP_001071122.1  tumor necrosis factor alpha-induced protein 8 isoform b

    See identical proteins and their annotated locations for NP_001071122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5'-terminal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC035144, BC007014, BP274520, CB241243
    Consensus CDS
    CCDS47257.1
    UniProtKB/Swiss-Prot
    O95379
    Related
    ENSP00000274456.6, ENST00000274456.6
    Conserved Domains (1) summary
    pfam05527
    Location:7185
    DUF758; Domain of unknown function (DUF758)
  2. NM_001286813.2NP_001273742.1  tumor necrosis factor alpha-induced protein 8 isoform a

    See identical proteins and their annotated locations for NP_001273742.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AC035144, AK097284, BC007014, CB241243
    Consensus CDS
    CCDS47258.1
    UniProtKB/Swiss-Prot
    O95379, Q9UP47
    UniProtKB/TrEMBL
    B3KUI2
    Related
    ENSP00000421848.1, ENST00000503646.1
    Conserved Domains (1) summary
    pfam05527
    Location:17195
    DUF758; Domain of unknown function (DUF758)
  3. NM_001286814.1NP_001273743.1  tumor necrosis factor alpha-induced protein 8 isoform c

    See identical proteins and their annotated locations for NP_001273743.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5'-terminal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a longer and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AK301281, BC007014, CB241243, DC391074
    Consensus CDS
    CCDS68933.1
    UniProtKB/Swiss-Prot
    O95379
    Related
    ENSP00000427424.1, ENST00000513374.1
    Conserved Domains (1) summary
    pfam05527
    Location:29207
    DUF758; Domain of unknown function (DUF758)
  4. NM_001286815.2NP_001273744.1  tumor necrosis factor alpha-induced protein 8 isoform d

    See identical proteins and their annotated locations for NP_001273744.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Both variants 5 and 6 encode the same isoform.
    Source sequence(s)
    AC035144, BC007014, BP274520, CB241243, DB114867
    UniProtKB/Swiss-Prot
    O95379
    Conserved Domains (1) summary
    pfam05527
    Location:1163
    DUF758; Domain of unknown function (DUF758)
  5. NM_001286817.2NP_001273746.1  tumor necrosis factor alpha-induced protein 8 isoform d

    See identical proteins and their annotated locations for NP_001273746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Both variants 5 and 6 encode the same isoform.
    Source sequence(s)
    AC035144, BC007014, BP274520, CB241243, DB124282
    UniProtKB/Swiss-Prot
    O95379
    Conserved Domains (1) summary
    pfam05527
    Location:1163
    DUF758; Domain of unknown function (DUF758)
  6. NM_014350.4NP_055165.2  tumor necrosis factor alpha-induced protein 8 isoform a

    See identical proteins and their annotated locations for NP_055165.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Both variant 1 and 3 encode the same isoform.
    Source sequence(s)
    AC035144, BC007014, CB241243
    Consensus CDS
    CCDS47258.1
    UniProtKB/Swiss-Prot
    O95379, Q9UP47
    Related
    ENSP00000422245.1, ENST00000504771.3
    Conserved Domains (1) summary
    pfam05527
    Location:17195
    DUF758; Domain of unknown function (DUF758)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    119268759..119399688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009328.2XP_016864817.1  tumor necrosis factor alpha-induced protein 8 isoform X2

    Conserved Domains (1) summary
    pfam05527
    Location:1163
    DUF758; Domain of unknown function (DUF758)
  2. XM_047417082.1XP_047273038.1  tumor necrosis factor alpha-induced protein 8 isoform X2

  3. XM_017009327.2XP_016864816.1  tumor necrosis factor alpha-induced protein 8 isoform X1

  4. XM_047417081.1XP_047273037.1  tumor necrosis factor alpha-induced protein 8 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    119789607..119920525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)