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RASGRP3 RAS guanyl releasing protein 3 [ Homo sapiens (human) ]

Gene ID: 25780, updated on 1-Aug-2020

Summary

Official Symbol
RASGRP3provided by HGNC
Official Full Name
RAS guanyl releasing protein 3provided by HGNC
Primary source
HGNC:HGNC:14545
See related
Ensembl:ENSG00000152689 MIM:609531
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRP3
Summary
The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]
Expression
Broad expression in lymph node (RPKM 8.7), appendix (RPKM 6.4) and 22 other tissues See more
Orthologs

Genomic context

See RASGRP3 in Genome Data Viewer
Location:
2p22.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (33436348..33564731)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (33661416..33789798)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene latent transforming growth factor beta binding protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 92 Neighboring gene microRNA 4430 Neighboring gene RASGRP3 antisense RNA 1 Neighboring gene uncharacterized LOC105374455 Neighboring gene ATPase H+ transporting V0 subunit e1 pseudogene 3 Neighboring gene family with sequence similarity 98 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
NHGRI GWA Catalog
Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan.
NHGRI GWA Catalog
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0846

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Ras guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
diacylglycerol binding NAS
Non-traceable Author Statement
more info
PubMed 
guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade NAS
Non-traceable Author Statement
more info
PubMed 
MAPK cascade TAS
Traceable Author Statement
more info
 
Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
guanyl-nucleotide exchange factor complex IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ras guanyl-releasing protein 3
Names
CalDAG-GEFIII
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
calcium and DAG-regulated guanine nucleotide exchange factor III
calcium- and diacylglycerol-regulated guanine nucleotide exchange factor III
guanine nucleotide exchange factor for Rap1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053077.1 RefSeqGene

    Range
    5001..133384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001139488.2NP_001132960.1  ras guanyl-releasing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001132960.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, and 4-6 all encode the same isoform (1).
    Source sequence(s)
    AA351079, BC027849, BX647990, DA336406, DA439087
    Consensus CDS
    CCDS46256.1
    UniProtKB/Swiss-Prot
    Q8IV61
    Related
    ENSP00000384192.3, ENST00000403687.8
    Conserved Domains (4) summary
    cd06224
    Location:11126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:495544
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:428478
    EF-hand_7; EF-hand domain pair
  2. NM_001349975.2NP_001336904.1  ras guanyl-releasing protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).
    Source sequence(s)
    AC020594
    Consensus CDS
    CCDS46256.1
    Conserved Domains (4) summary
    cd06224
    Location:11126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:495544
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:428478
    EF-hand_7; EF-hand domain pair
  3. NM_001349976.2NP_001336905.1  ras guanyl-releasing protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).
    Source sequence(s)
    AC020594
    Consensus CDS
    CCDS46256.1
    Conserved Domains (4) summary
    cd06224
    Location:11126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:495544
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:428478
    EF-hand_7; EF-hand domain pair
  4. NM_001349977.2NP_001336906.1  ras guanyl-releasing protein 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents the longest transcript and differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).
    Source sequence(s)
    AC020594
    Consensus CDS
    CCDS46256.1
    Conserved Domains (4) summary
    cd06224
    Location:11126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:495544
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:428478
    EF-hand_7; EF-hand domain pair
  5. NM_001349978.2NP_001336907.1  ras guanyl-releasing protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).
    Source sequence(s)
    AC020594
    Consensus CDS
    CCDS54346.1
    Conserved Domains (4) summary
    cd06224
    Location:11126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:494543
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:427477
    EF-hand_7; EF-hand domain pair
  6. NM_001349979.2NP_001336908.1  ras guanyl-releasing protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).
    Source sequence(s)
    AC020594
    Consensus CDS
    CCDS54346.1
    Conserved Domains (4) summary
    cd06224
    Location:11126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:494543
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:427477
    EF-hand_7; EF-hand domain pair
  7. NM_001349980.2NP_001336909.1  ras guanyl-releasing protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).
    Source sequence(s)
    AC020594
    Consensus CDS
    CCDS54346.1
    Conserved Domains (4) summary
    cd06224
    Location:11126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:494543
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:427477
    EF-hand_7; EF-hand domain pair
  8. NM_001349981.2NP_001336910.1  ras guanyl-releasing protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).
    Source sequence(s)
    AC020594
    Consensus CDS
    CCDS54346.1
    Conserved Domains (4) summary
    cd06224
    Location:11126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:494543
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:427477
    EF-hand_7; EF-hand domain pair
  9. NM_015376.2NP_056191.1  ras guanyl-releasing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_056191.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).
    Source sequence(s)
    AA351079, AB020653, BC027849, BX114300, BX647990
    Consensus CDS
    CCDS54346.1
    UniProtKB/Swiss-Prot
    Q8IV61
    Related
    ENSP00000383917.1, ENST00000407811.5
    Conserved Domains (4) summary
    cd06224
    Location:11126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:494543
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:427477
    EF-hand_7; EF-hand domain pair
  10. NM_170672.3NP_733772.1  ras guanyl-releasing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_733772.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).
    Source sequence(s)
    AA351079, AC020594, BC027849, BX647990, DA439087
    Consensus CDS
    CCDS46256.1
    UniProtKB/Swiss-Prot
    Q8IV61
    Related
    ENSP00000385886.3, ENST00000402538.7
    Conserved Domains (4) summary
    cd06224
    Location:11126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:495544
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:428478
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    33436348..33564731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003759.2XP_016859248.1  ras guanyl-releasing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q8IV61
    Conserved Domains (4) summary
    cd06224
    Location:11126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:495544
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:428478
    EF-hand_7; EF-hand domain pair
  2. XM_011532746.3XP_011531048.1  ras guanyl-releasing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011531048.1

    UniProtKB/Swiss-Prot
    Q8IV61
    Conserved Domains (4) summary
    cd06224
    Location:11126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:495544
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:428478
    EF-hand_7; EF-hand domain pair
  3. XM_011532748.3XP_011531050.2  ras guanyl-releasing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q8IV61
    Conserved Domains (4) summary
    cd06224
    Location:11126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:495544
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:428478
    EF-hand_7; EF-hand domain pair
  4. XM_017003761.2XP_016859250.1  ras guanyl-releasing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q8IV61
    Conserved Domains (4) summary
    cd06224
    Location:11126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:495544
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:428478
    EF-hand_7; EF-hand domain pair

RNA

  1. XR_001738693.2 RNA Sequence

  2. XR_001738692.2 RNA Sequence

  3. XR_001738691.2 RNA Sequence

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