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CBY1 chibby family member 1, beta catenin antagonist [ Homo sapiens (human) ]

Gene ID: 25776, updated on 1-Jun-2020

Summary

Official Symbol
CBY1provided by HGNC
Official Full Name
chibby family member 1, beta catenin antagonistprovided by HGNC
Primary source
HGNC:HGNC:1307
See related
Ensembl:ENSG00000100211 MIM:607757
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBY; arb1; PGEA1; C22orf2; Chibby1; PIGEA14; PIGEA-14; HS508I15A
Summary
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 16.6), adrenal (RPKM 16.3) and 25 other tissues See more
Orthologs

Genomic context

See CBY1 in Genome Data Viewer
Location:
22q13.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (38656653..38673850)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (39052658..39069859)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S29 pseudogene 31 Neighboring gene family with sequence similarity 227 member A Neighboring gene translocase of outer mitochondrial membrane 22 Neighboring gene Josephin domain containing 1 Neighboring gene GTP binding protein 1 Neighboring gene peroxiredoxin 3 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cardiac muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
centriole IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein chibby homolog 1
Names
ARPP-binding protein
PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
chibby CTNNB1-mediated transcription inhibitor
chibby homolog 1
coiled-coil protein PIGEA-14
cytosolic leucine-rich protein
polycystin-2 interactor, Golgi- and endoplasmic reticulum-associated protein, 14 kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047138.1 RefSeqGene

    Range
    5001..22198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001002880.1NP_001002880.2  protein chibby homolog 1 isoform b

    See identical proteins and their annotated locations for NP_001002880.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (b) is longer at the N-terminus compared to isoform a.
    Source sequence(s)
    AU099418, BC016139, CD626926
    Consensus CDS
    CCDS74861.1
    UniProtKB/Swiss-Prot
    Q9Y3M2
    UniProtKB/TrEMBL
    A0A087WUW0
    Related
    ENSP00000478962.1, ENST00000619293.1
    Conserved Domains (1) summary
    pfam14645
    Location:44157
    Chibby; Chibby family
  2. NM_015373.3NP_056188.1  protein chibby homolog 1 isoform a

    See identical proteins and their annotated locations for NP_056188.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform (a), which is shorter at the N-terminus compared to isoform b.
    Source sequence(s)
    AL136686, BC016139, CD702742
    Consensus CDS
    CCDS13974.1
    UniProtKB/Swiss-Prot
    Q9Y3M2
    UniProtKB/TrEMBL
    A0A024R1L9
    Related
    ENSP00000216029.3, ENST00000216029.7
    Conserved Domains (1) summary
    pfam14645
    Location:1114
    Chibby; Chibby family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    38656653..38673850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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