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GSTT4 glutathione S-transferase theta 4 [ Homo sapiens (human) ]

Gene ID: 25774, updated on 1-Oct-2022

Summary

Official Symbol
GSTT4provided by HGNC
Official Full Name
glutathione S-transferase theta 4provided by HGNC
Primary source
HGNC:HGNC:26930
See related
Ensembl:ENSG00000276950 AllianceGenome:HGNC:26930
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSTTP1; HS322B1A
Summary
Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 4.0) See more
Orthologs
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Genomic context

See GSTT4 in Genome Data Viewer
Location:
22q11.23
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (23989115..24005453, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (24405779..24412527, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24340595..24347350, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene D-dopachrome tautomerase like Neighboring gene D-dopachrome tautomerase Neighboring gene glutathione S-transferase theta 2 (gene/pseudogene) Neighboring gene uncharacterized LOC105372959 Neighboring gene calcineurin binding protein 1 Neighboring gene Sharpr-MPRA regulatory region 1007

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • MGC119755, MGC119756

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glutathione S-transferase theta-4
Names
GST class-theta-4
glutathione S-transferase theta pseudogene 1
NP_001345593.1
XP_024307967.1
XP_024307968.1
XP_024307970.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358664.2NP_001345593.1  glutathione S-transferase theta-4

    Status: VALIDATED

    Source sequence(s)
    AC253536
    Consensus CDS
    CCDS87011.1
    UniProtKB/Swiss-Prot
    A0A1W2PR19
    Related
    ENSP00000492273.1, ENST00000621179.6
    Conserved Domains (2) summary
    cd03183
    Location:91217
    GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    cl00388
    Location:378
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RNA

  1. NR_003081.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC253536
    Related
    ENST00000611600.4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    23989115..24005453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452202.2XP_024307970.1  glutathione S-transferase theta-4 isoform X3

    Conserved Domains (2) summary
    cl00388
    Location:781
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:100157
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
  2. XM_024452199.2XP_024307967.1  glutathione S-transferase theta-4 isoform X1

    Conserved Domains (2) summary
    cl00388
    Location:781
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:100198
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
  3. XM_024452200.2XP_024307968.1  glutathione S-transferase theta-4 isoform X2

    Conserved Domains (2) summary
    cl00388
    Location:3271
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:90188
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187633.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    234770..241525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    24405779..24412527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039498.1: Suppressed sequence

    Description
    NM_001039498.1: This RefSeq was permanently suppressed because we now believe this locus is a pseudogene rather than a protein-coding gene.
  2. NM_001040638.1: Suppressed sequence

    Description
    NM_001040638.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
  3. NM_015371.1: Suppressed sequence

    Description
    NM_015371.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidiate.