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HYPK huntingtin interacting protein K [ Homo sapiens (human) ]

Gene ID: 25764, updated on 7-Jun-2020

Summary

Official Symbol
HYPKprovided by HGNC
Official Full Name
huntingtin interacting protein Kprovided by HGNC
Primary source
HGNC:HGNC:18418
See related
Ensembl:ENSG00000242028 MIM:612784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC136; C15orf63
Expression
Ubiquitous expression in fat (RPKM 18.1), prostate (RPKM 18.1) and 25 other tissues See more
Orthologs

Genomic context

See HYPK in Genome Data Viewer
Location:
15q15.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (43800421..43804427)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (44092619..44094787)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene small EDRK-rich factor 2 Neighboring gene SERF2-C15orf63 readthrough Neighboring gene microRNA 1282 Neighboring gene serine incorporator 4 Neighboring gene microfibril associated protein 1 Neighboring gene WD repeat domain 76

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
huntingtin-interacting protein K
Names
huntingtin yeast partner K

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199885.1NP_001186814.1  huntingtin-interacting protein K isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC018512, BC019262, BQ478474, BQ772100
    UniProtKB/Swiss-Prot
    Q9NX55
  2. NM_016400.4NP_057484.4  huntingtin-interacting protein K isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC018512
    Consensus CDS
    CCDS10104.1
    Related
    ENSP00000401155.2, ENST00000442995.2
    Conserved Domains (1) summary
    cd14361
    Location:80120
    UBA_HYPK; UBA-like domain found in Huntingtin-interacting protein K (HYPK) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    43800421..43804427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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