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Il2rb interleukin 2 receptor subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 25746, updated on 25-Nov-2021

Summary

Official Symbol
Il2rbprovided by RGD
Official Full Name
interleukin 2 receptor subunit betaprovided by RGD
Primary source
RGD:2896
See related
EnsemblRapid:ENSRNOG00000048636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IL2RBC
Summary
beta chain of receptor for interleukin 2 [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 154.6), Lung (RPKM 92.0) and 7 other tissues See more
Orthologs
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Genomic context

See Il2rb in Genome Data Viewer
Location:
7q34
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110033341..110048054, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (119701338..119716238, complement)

Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 17 Neighboring gene transmembrane serine protease 6 Neighboring gene uncharacterized LOC102547102 Neighboring gene uncharacterized LOC120093823 Neighboring gene uncharacterized LOC120093686 Neighboring gene C1q and TNF related 6

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-15 receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-15 receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-15 receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables interleukin-2 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-2 binding IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-2 binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables interleukin-2 binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-2 binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables interleukin-2 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-2 receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-2 receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to interleukin-2 receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-2 receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-2 receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine-mediated signaling pathway IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-15-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-15-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-15-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in interleukin-2-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-2-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-2-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in natural killer cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in natural killer cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
interleukin-2 receptor subunit beta
Names
IL-2 receptor subunit beta
IL-2R subunit beta
IL-2RB
P70-75
high affinity IL-2 receptor subunit beta
interleukin 2 receptor, beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013195.2NP_037327.2  interleukin-2 receptor subunit beta precursor

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000186
    Related
    ENSRNOP00000075262.1, ENSRNOT00000077438.2
    Conserved Domains (2) summary
    cd00063
    Location:135232
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18707
    Location:32123
    IL2RB_N1; Interleukin-2 receptor subunit beta N-terminal domain 1

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

    Range
    110033341..110048054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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