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S100b S100 calcium binding protein B [ Rattus norvegicus (Norway rat) ]

Gene ID: 25742, updated on 24-Apr-2022

Summary

Official Symbol
S100bprovided by RGD
Official Full Name
S100 calcium binding protein Bprovided by RGD
Primary source
RGD:3615
See related
AllianceGenome:RGD:3615
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
S100P
Summary
Enables RAGE receptor binding activity; identical protein binding activity; and metal ion binding activity. Involved in several processes, including long-term synaptic potentiation; negative regulation of skeletal muscle cell differentiation; and positive regulation of myelination. Located in cytoplasm and extracellular space. Used to study demyelinating disease. Biomarker of several diseases, including bipolar disorder; borna disease; brain disease (multiple); mental depression; and sleep apnea. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; aspergillosis; and schizophrenia. Orthologous to human S100B (S100 calcium binding protein B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 2647.5), Adrenal (RPKM 351.8) and 1 other tissue See more
Orthologs
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Genomic context

See S100b in Genome Data Viewer
Location:
20p12
Exon count:
5
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12372866..12381619, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13130633..13142856, complement)

Chromosome 20 - NC_051355.1Genomic Context describing neighboring genes Neighboring gene pericentrin Neighboring gene disco-interacting protein 2 homolog A Neighboring gene U6 spliceosomal RNA Neighboring gene protein arginine methyltransferase 2 Neighboring gene microRNA 678

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC93559

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RAGE receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RAGE receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RAGE receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables S100 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables S100 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tau protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in astrocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in long-term synaptic potentiation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within memory ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to methylmercury IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein S100-B
Names
S-100 protein beta chain
S-100 protein subunit beta
S100 calcium-binding protein, beta (neural)
S100 protein, beta polypeptide, neural

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013191.2NP_037323.1  protein S100-B

    See identical proteins and their annotated locations for NP_037323.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000324
    UniProtKB/Swiss-Prot
    P04631
    Conserved Domains (1) summary
    cd05027
    Location:289
    S-100B; S-100B domain found in proteins similar to S100B. S100B is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which this ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051355.1 Reference mRatBN7.2 Primary Assembly

    Range
    12372866..12381619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772868.2XP_008771090.1  protein S100-B isoform X1

    See identical proteins and their annotated locations for XP_008771090.1

    UniProtKB/Swiss-Prot
    P04631
    Conserved Domains (1) summary
    cd05027
    Location:289
    S-100B; S-100B domain found in proteins similar to S100B. S100B is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which this ...
  2. XM_017601568.2XP_017457057.1  protein S100-B isoform X1

    UniProtKB/Swiss-Prot
    P04631
    Conserved Domains (1) summary
    cd05027
    Location:289
    S-100B; S-100B domain found in proteins similar to S100B. S100B is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which this ...