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FAM133B family with sequence similarity 133 member B [ Homo sapiens (human) ]

Gene ID: 257415, updated on 1-Jun-2020

Summary

Official Symbol
FAM133Bprovided by HGNC
Official Full Name
family with sequence similarity 133 member Bprovided by HGNC
Primary source
HGNC:HGNC:28629
See related
Ensembl:ENSG00000234545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in bone marrow (RPKM 9.6), lymph node (RPKM 5.2) and 25 other tissues See more
Orthologs

Genomic context

See FAM133B in Genome Data Viewer
Location:
7q21.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (92560758..92590390, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (92190072..92219706, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene GATA zinc finger domain containing 1 Neighboring gene peroxisomal biogenesis factor 1 Neighboring gene RNA binding motif protein 48 Neighboring gene uncharacterized LOC105375397 Neighboring gene uncharacterized LOC112268009 Neighboring gene cyclin dependent kinase 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC40405

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040057.3NP_001035146.1  protein FAM133B isoform 2

    See identical proteins and their annotated locations for NP_001035146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 5' region, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    BC057771, BC062706, BU581457
    Consensus CDS
    CCDS47641.1
    UniProtKB/Swiss-Prot
    Q5BKY9
    Related
    ENSP00000389783.1, ENST00000438306.5
  2. NM_001288584.2NP_001275513.1  protein FAM133B isoform 2

    See identical proteins and their annotated locations for NP_001275513.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate 5' terminal exon, lacks a portion of the 5' coding region and initiates translation at a downsteream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK313692, BC032461, BU581457
    Consensus CDS
    CCDS47641.1
    UniProtKB/Swiss-Prot
    Q5BKY9
    Related
    ENSP00000402843.1, ENST00000427372.5
  3. NM_152789.4NP_690002.2  protein FAM133B isoform 1

    See identical proteins and their annotated locations for NP_690002.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC062706, BC090868, BU581457
    Consensus CDS
    CCDS47640.1
    UniProtKB/Swiss-Prot
    Q5BKY9
    Related
    ENSP00000398401.1, ENST00000445716.6

RNA

  1. NR_109929.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC032461, BC062706, BU581457, BX337761
    Related
    ENST00000415397.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    92560758..92590390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516005.3XP_011514307.1  protein FAM133B isoform X2

  2. XM_011516004.3XP_011514306.1  protein FAM133B isoform X1

    See identical proteins and their annotated locations for XP_011514306.1

    UniProtKB/Swiss-Prot
    Q5BKY9
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