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TAB3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 [ Homo sapiens (human) ]

Gene ID: 257397, updated on 11-Jun-2021

Summary

Official Symbol
TAB3provided by HGNC
Official Full Name
TGF-beta activated kinase 1 (MAP3K7) binding protein 3provided by HGNC
Primary source
HGNC:HGNC:30681
See related
Ensembl:ENSG00000157625 MIM:300480
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAP1; MAP3K7IP3
Summary
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 6.3), endometrium (RPKM 5.6) and 25 other tissues See more
Orthologs
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Genomic context

See TAB3 in Genome Data Viewer
Location:
Xp21.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (30827442..30889391, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (30845559..30907371, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene myoneurin pseudogene Neighboring gene GK antisense RNA 1 Neighboring gene TAB3 antisense RNA 1 Neighboring gene glycerol kinase Neighboring gene ferritin heavy chain like 17 Neighboring gene dystrophin Neighboring gene RNA, U6 small nuclear 894, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr The ability of HIV-1 Vpr to activate NF-kappaB or activator protein 1-dependent luciferase expression requires TAK1, TRAF6, or TAB3 in cells PubMed
capsid gag The TAK1 kinase complex (TAK1/TAB2/TAB3) contributes to capsid-specific restriction mediated by TRIM5alpha. TRIM5alpha activates TAK1 autophosphorylation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC45404

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
involved_in JNK cascade TAS
Traceable Author Statement
more info
 
involved_in MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in activation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of MAPK activity TAS
Traceable Author Statement
more info
 
involved_in cytoplasmic pattern recognition receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in negative regulation of autophagy TAS
Traceable Author Statement
more info
PubMed 
involved_in nucleotide-binding oligomerization domain containing signaling pathway TAS
Traceable Author Statement
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
 
involved_in stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome membrane TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
Names
NF-kappa-B-activating protein 1
NFkB activating protein 1
TAB-3
TAK1-binding protein 3
TGF-beta activated kinase 1 and MAP3K7 binding protein 3
TGF-beta-activated kinase 1-binding protein 3
mitogen-activated protein kinase kinase kinase 7 interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012845.2 RefSeqGene

    Range
    5141..66953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_152787.5NP_690000.3  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

    See identical proteins and their annotated locations for NP_690000.3

    Status: REVIEWED

    Source sequence(s)
    AC108359, AC117405, AK096786, BC032526, DA494641
    Consensus CDS
    CCDS14226.1
    UniProtKB/Swiss-Prot
    Q8N5C8
    Related
    ENSP00000368215.1, ENST00000378933.5
    Conserved Domains (4) summary
    smart00547
    Location:687709
    ZnF_RBZ; Zinc finger domain
    PRK10263
    Location:245345
    PRK10263; DNA translocase FtsK; Provisional
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    sd00029
    Location:687706
    zf-RanBP2; RanBP2-type Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    30827442..30889391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274484.2XP_005274541.2  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X3

    See identical proteins and their annotated locations for XP_005274541.2

    Conserved Domains (4) summary
    smart00547
    Location:653675
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    sd00029
    Location:653672
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam03153
    Location:122291
    TFIIA; Transcription factor IIA, alpha/beta subunit
  2. XM_005274483.3XP_005274540.2  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2

    See identical proteins and their annotated locations for XP_005274540.2

    UniProtKB/Swiss-Prot
    Q8N5C8
    Related
    ENSP00000368214.2, ENST00000378932.6
    Conserved Domains (4) summary
    smart00547
    Location:659681
    ZnF_RBZ; Zinc finger domain
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    sd00029
    Location:659678
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cl28087
    Location:245345
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  3. XM_017029401.1XP_016884890.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X4

  4. XM_017029399.1XP_016884888.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

    Conserved Domains (3) summary
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    pfam03153
    Location:122291
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam13900
    Location:634681
    GVQW; Putative domain of unknown function
  5. XM_017029400.1XP_016884889.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

    Related
    ENSP00000433193.1, ENST00000467136.5
    Conserved Domains (3) summary
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    pfam03153
    Location:122291
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam13900
    Location:634681
    GVQW; Putative domain of unknown function
  6. XM_011545488.2XP_011543790.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X5

    Conserved Domains (2) summary
    cd14362
    Location:950
    CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
    pfam03153
    Location:122291
    TFIIA; Transcription factor IIA, alpha/beta subunit
  7. XM_017029402.1XP_016884891.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X6

RNA

  1. XR_950434.1 RNA Sequence

  2. XR_950433.1 RNA Sequence

  3. XR_001755682.1 RNA Sequence

  4. XR_430492.1 RNA Sequence

  5. XR_950435.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198312.1: Suppressed sequence

    Description
    NM_198312.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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