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Acp5 acid phosphatase 5, tartrate resistant [ Rattus norvegicus (Norway rat) ]

Gene ID: 25732, updated on 18-Apr-2019

Summary

Official Symbol
Acp5provided by RGD
Official Full Name
acid phosphatase 5, tartrate resistantprovided by RGD
Primary source
RGD:2022
See related
Ensembl:ENSRNOG00000046261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Trap; TTRRAP
Summary
tartrate-resistant acid phosphatase; may be involved in bone resorption; 5b isoform is osteoclast-specific and may be a specific marker of bone resorption [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 417.2), Kidney (RPKM 210.0) and 4 other tissues See more
Orthologs

Genomic context

See Acp5 in Genome Data Viewer
Location:
8q13
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (23142733..23149067, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (23197095..23202903, complement)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene calponin 1 Neighboring gene elongation factor 1 homolog Neighboring gene rCG31672-like Neighboring gene zinc finger protein 709-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acid phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
acid phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
acid phosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
acid phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
ferric iron binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ferric iron binding IEA
Inferred from Electronic Annotation
more info
 
ferric iron binding ISO
Inferred from Sequence Orthology
more info
PubMed 
ferric iron binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ferrous iron binding IEA
Inferred from Electronic Annotation
more info
 
ferrous iron binding ISO
Inferred from Sequence Orthology
more info
PubMed 
ferrous iron binding ISS
Inferred from Sequence or Structural Similarity
more info
 
hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
bone morphogenesis IEA
Inferred from Electronic Annotation
more info
 
bone morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bone resorption IEA
Inferred from Electronic Annotation
more info
 
bone resorption IEP
Inferred from Expression Pattern
more info
PubMed 
bone resorption ISO
Inferred from Sequence Orthology
more info
PubMed 
bone resorption TAS
Traceable Author Statement
more info
PubMed 
defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
PubMed 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
dephosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
multicellular organismal response to stress IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of superoxide anion generation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
PubMed 
ossification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ossification IEP
Inferred from Expression Pattern
more info
PubMed 
osteoclast differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to L-ascorbic acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to cholesterol IEP
Inferred from Expression Pattern
more info
PubMed 
response to cytokine IEA
Inferred from Electronic Annotation
more info
 
response to cytokine ISO
Inferred from Sequence Orthology
more info
PubMed 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to zinc ion IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
PubMed 
lysosome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
tartrate-resistant acid phosphatase type 5
Names
TR-AP
acid phosphatase type V
tartrate-resistant acid ATPase
trATPase
type 5 acid phosphatase
NP_001257818.1
NP_062017.2
XP_006242754.1
XP_006242755.1
XP_006242756.1
XP_017450976.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270889.1NP_001257818.1  tartrate-resistant acid phosphatase type 5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001257818.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC078847, BM386942
    UniProtKB/Swiss-Prot
    P29288
    Related
    ENSRNOP00000066364.1, ENSRNOT00000075237.2
    Conserved Domains (2) summary
    cd07378
    Location:28313
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
    pfam00149
    Location:28244
    Metallophos; Calcineurin-like phosphoesterase
  2. NM_019144.2NP_062017.2  tartrate-resistant acid phosphatase type 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_062017.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC078847, BM386942, CV074238
    UniProtKB/Swiss-Prot
    P29288
    UniProtKB/TrEMBL
    A0A0G2K6Z6
    Related
    ENSRNOP00000074001.1, ENSRNOT00000092200.1
    Conserved Domains (2) summary
    cd07378
    Location:36321
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
    pfam00149
    Location:36252
    Metallophos; Calcineurin-like phosphoesterase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    23142733..23149067 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242693.3XP_006242755.1  tartrate-resistant acid phosphatase type 5 isoform X2

    See identical proteins and their annotated locations for XP_006242755.1

    UniProtKB/Swiss-Prot
    P29288
    Conserved Domains (2) summary
    cd07378
    Location:28313
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
    pfam00149
    Location:28244
    Metallophos; Calcineurin-like phosphoesterase
  2. XM_006242692.3XP_006242754.1  tartrate-resistant acid phosphatase type 5 isoform X2

    See identical proteins and their annotated locations for XP_006242754.1

    UniProtKB/Swiss-Prot
    P29288
    Conserved Domains (2) summary
    cd07378
    Location:28313
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
    pfam00149
    Location:28244
    Metallophos; Calcineurin-like phosphoesterase
  3. XM_017595487.1XP_017450976.1  tartrate-resistant acid phosphatase type 5 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K6Z6
    Conserved Domains (2) summary
    cd07378
    Location:36321
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
    pfam00149
    Location:36252
    Metallophos; Calcineurin-like phosphoesterase
  4. XM_006242694.2XP_006242756.1  tartrate-resistant acid phosphatase type 5 isoform X2

    See identical proteins and their annotated locations for XP_006242756.1

    UniProtKB/Swiss-Prot
    P29288
    Conserved Domains (2) summary
    cd07378
    Location:28313
    MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain
    pfam00149
    Location:28244
    Metallophos; Calcineurin-like phosphoesterase

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    22052728..22058674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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