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UTS2B urotensin 2B [ Homo sapiens (human) ]

Gene ID: 257313, updated on 9-Dec-2024

Summary

Official Symbol
UTS2Bprovided by HGNC
Official Full Name
urotensin 2Bprovided by HGNC
Primary source
HGNC:HGNC:30894
See related
Ensembl:ENSG00000188958 MIM:618134; AllianceGenome:HGNC:30894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
U2B; URP; UIIB; U-IIB; UTS2D
Summary
Predicted to enable G protein-coupled receptor binding activity. Predicted to be involved in regulation of blood pressure. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See UTS2B in Genome Data Viewer
Location:
3q28
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (191267168..191346182, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (194081889..194166084, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (190984957..191048315, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986171 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:190875631-190876830 Neighboring gene NANOG hESC enhancer GRCh37_chr3:190909180-190909700 Neighboring gene OSTN antisense RNA 1 Neighboring gene osteocrin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20990 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:191019724-191020249 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:191046750-191047351 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:191047352-191047952 Neighboring gene coiled-coil domain containing 50 Neighboring gene Sharpr-MPRA regulatory region 6572 Neighboring gene PYDC2 antisense RNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_67093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:191217087-191217641 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:191217642-191218195 Neighboring gene pyrin domain containing 2 Neighboring gene uncharacterized LOC124909472

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC138371

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in blood vessel diameter maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
urotensin-2B
Names
prepro-URP
urotensin 2 domain containing
urotensin II-related peptide
urotensin IIB
urotensin-2 domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198152.5NP_937795.2  urotensin-2B precursor

    See identical proteins and their annotated locations for NP_937795.2

    Status: VALIDATED

    Source sequence(s)
    AC068645, AC126567
    Consensus CDS
    CCDS3300.1
    UniProtKB/Swiss-Prot
    B3KQY8, D3DNW1, Q2M1Z2, Q765I0
    Related
    ENSP00000340526.5, ENST00000340524.10
    Conserved Domains (1) summary
    PLN02531
    Location:89116
    PLN02531; GTP cyclohydrolase I

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    191267168..191346182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447899.1XP_047303855.1  urotensin-2B isoform X2

    UniProtKB/Swiss-Prot
    B3KQY8, D3DNW1, Q2M1Z2, Q765I0
  2. XM_011512631.3XP_011510933.1  urotensin-2B isoform X2

    See identical proteins and their annotated locations for XP_011510933.1

    UniProtKB/Swiss-Prot
    B3KQY8, D3DNW1, Q2M1Z2, Q765I0
    Related
    ENSP00000398761.2, ENST00000427544.6
    Conserved Domains (1) summary
    PLN02531
    Location:89116
    PLN02531; GTP cyclohydrolase I
  3. XM_017006091.2XP_016861580.1  urotensin-2B isoform X1

    UniProtKB/TrEMBL
    F8WCV4
    Related
    ENSP00000415628.1, ENST00000446788.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    194081889..194166084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346015.1XP_054201990.1  urotensin-2B isoform X2

  2. XM_054346014.1XP_054201989.1  urotensin-2B isoform X2

  3. XM_054346013.1XP_054201988.1  urotensin-2B isoform X1