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UTS2B urotensin 2B [ Homo sapiens (human) ]

Gene ID: 257313, updated on 5-Aug-2022

Summary

Official Symbol
UTS2Bprovided by HGNC
Official Full Name
urotensin 2Bprovided by HGNC
Primary source
HGNC:HGNC:30894
See related
Ensembl:ENSG00000188958 MIM:618134; AllianceGenome:HGNC:30894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
U2B; URP; UIIB; U-IIB; UTS2D
Summary
Predicted to enable G protein-coupled receptor binding activity. Predicted to be involved in regulation of blood pressure. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See UTS2B in Genome Data Viewer
Location:
3q28
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (191267168..191346182, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (194082873..194146571, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (190984957..191048315, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986171 Neighboring gene OSTN antisense RNA 1 Neighboring gene osteocrin Neighboring gene coiled-coil domain containing 50 Neighboring gene Sharpr-MPRA regulatory region 6572 Neighboring gene PYDC2 antisense RNA 1 Neighboring gene pyrin domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138371

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in blood vessel diameter maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
urotensin-2B
Names
prepro-URP
urotensin 2 domain containing
urotensin II-related peptide
urotensin IIB
urotensin-2 domain-containing protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198152.5NP_937795.2  urotensin-2B precursor

    See identical proteins and their annotated locations for NP_937795.2

    Status: VALIDATED

    Source sequence(s)
    AC068645, AC126567
    Consensus CDS
    CCDS3300.1
    UniProtKB/Swiss-Prot
    Q2M1Z2, Q765I0
    Related
    ENSP00000340526.5, ENST00000340524.10
    Conserved Domains (1) summary
    PLN02531
    Location:89116
    PLN02531; GTP cyclohydrolase I

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    191267168..191346182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447899.1XP_047303855.1  urotensin-2B isoform X2

    UniProtKB/Swiss-Prot
    Q2M1Z2
  2. XM_011512631.3XP_011510933.1  urotensin-2B isoform X2

    See identical proteins and their annotated locations for XP_011510933.1

    UniProtKB/Swiss-Prot
    Q2M1Z2, Q765I0
    Related
    ENSP00000398761.2, ENST00000427544.6
    Conserved Domains (1) summary
    PLN02531
    Location:89116
    PLN02531; GTP cyclohydrolase I
  3. XM_017006091.2XP_016861580.1  urotensin-2B isoform X1

    UniProtKB/TrEMBL
    F8WCV4
    Related
    ENSP00000415628.1, ENST00000446788.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    194082873..194146571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)