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Syt3 synaptotagmin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25731, updated on 12-Aug-2018

Summary

Official Symbol
Syt3provided by RGD
Official Full Name
synaptotagmin 3provided by RGD
Primary source
RGD:3805
See related
Ensembl:ENSRNOG00000019318
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SIII
Summary
member of the synaptotagmin family; brain specific calcium/phospholipid-binding protein; essential for calcium-dependent synaptic vesicle exocytosis; may be the calcium sensor for fast calcium-triggered neurotransmitter release [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 85.2), Heart (RPKM 12.8) and 3 other tissues See more
Orthologs

Genomic context

See Syt3 in Genome Data Viewer
Location:
1q22
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100379236..100407862)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (101459003..101473576)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene SH3 and multiple ankyrin repeat domains 1 Neighboring gene hypothetical LOC292874 Neighboring gene uncharacterized LOC108349570 Neighboring gene leucine rich repeat containing 4B

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
syntaxin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
calcium ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion regulated exocytosis IEA
Inferred from Electronic Annotation
more info
 
calcium ion regulated exocytosis TAS
Traceable Author Statement
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of dendrite extension IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vesicle fusion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of calcium ion-dependent exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle exocytosis TAS
Traceable Author Statement
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
endosome IEA
Inferred from Electronic Annotation
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of synaptic membrane EXP
Inferred from Experiment
more info
PubMed 
integral component of synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynapse IEA
Inferred from Electronic Annotation
more info
 
synapse NAS
Non-traceable Author Statement
more info
PubMed 
transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
synaptotagmin-3
Names
synaptotagmin III
sytIII

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019122.1NP_061995.1  synaptotagmin-3

    See identical proteins and their annotated locations for NP_061995.1

    Status: PROVISIONAL

    Source sequence(s)
    D28512
    UniProtKB/Swiss-Prot
    P40748
    Related
    ENSRNOP00000026251.2, ENSRNOT00000026251.4
    Conserved Domains (2) summary
    cd08385
    Location:297422
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:431565
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    100379236..100407862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759325.2XP_008757547.1  synaptotagmin-3 isoform X1

    See identical proteins and their annotated locations for XP_008757547.1

    UniProtKB/Swiss-Prot
    P40748
    UniProtKB/TrEMBL
    A0A0G2JSR2
    Conserved Domains (2) summary
    cd08385
    Location:297422
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:431565
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
  2. XM_006228979.3XP_006229041.1  synaptotagmin-3 isoform X1

    See identical proteins and their annotated locations for XP_006229041.1

    UniProtKB/Swiss-Prot
    P40748
    UniProtKB/TrEMBL
    A0A0G2JSR2
    Conserved Domains (2) summary
    cd08385
    Location:297422
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:431565
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
  3. XM_006228978.3XP_006229040.1  synaptotagmin-3 isoform X1

    See identical proteins and their annotated locations for XP_006229040.1

    UniProtKB/Swiss-Prot
    P40748
    UniProtKB/TrEMBL
    A0A0G2JSR2
    Conserved Domains (2) summary
    cd08385
    Location:297422
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:431565
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
  4. XM_017588833.1XP_017444322.1  synaptotagmin-3 isoform X1

    UniProtKB/Swiss-Prot
    P40748
    UniProtKB/TrEMBL
    A0A0G2JSR2
    Conserved Domains (2) summary
    cd08385
    Location:297422
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:431565
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    89144345..89157982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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