Format

Send to:

Choose Destination

Ccne1 cyclin E1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25729, updated on 9-Sep-2018

Summary

Official Symbol
Ccne1provided by RGD
Official Full Name
cyclin E1provided by RGD
Primary source
RGD:2294
See related
Ensembl:ENSRNOG00000014786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccne; CYCLE
Summary
a cyclin-like protein; may be involved in growth stimulation [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 120.2), Thymus (RPKM 85.8) and 9 other tissues See more
Orthologs

Genomic context

See Ccne1 in Genome Data Viewer
Location:
1q21
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (94485830..94495112, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (95575136..95584387, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene URI1, prefoldin-like chaperone Neighboring gene uncharacterized LOC108349566 Neighboring gene similar to mitochondrial ribosomal protein L32 Neighboring gene similar to CG3740-PA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein serine/threonine kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
DNA replication initiation ISO
Inferred from Sequence Orthology
more info
 
G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
animal organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
antral ovarian follicle growth IEP
Inferred from Expression Pattern
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
chromosome organization involved in meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
liver development IEP
Inferred from Expression Pattern
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular protein localization ISO
Inferred from Sequence Orthology
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
response to corticosterone IEP
Inferred from Expression Pattern
more info
PubMed 
response to cytokine IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to methylmercury IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to progesterone IEP
Inferred from Expression Pattern
more info
PubMed 
response to purine-containing compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to steroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin E IEP
Inferred from Expression Pattern
more info
PubMed 
synapsis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapsis IEA
Inferred from Electronic Annotation
more info
 
synapsis ISO
Inferred from Sequence Orthology
more info
 
telomere maintenance IEA
Inferred from Electronic Annotation
more info
 
telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cyclin E1-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin E1-CDK2 complex IEA
Inferred from Electronic Annotation
more info
 
cyclin E1-CDK2 complex ISO
Inferred from Sequence Orthology
more info
 
cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
G1/S-specific cyclin-E1
Names
cyclin E

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100821.1NP_001094291.1  G1/S-specific cyclin-E1

    See identical proteins and their annotated locations for NP_001094291.1

    Status: VALIDATED

    Source sequence(s)
    BU760054, CK842479, DY561075, EV771022
    UniProtKB/TrEMBL
    B1WC54
    Conserved Domains (2) summary
    pfam00134
    Location:116243
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:246365
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    94485830..94495112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228904.3XP_006228966.1  G1/S-specific cyclin-E1 isoform X1

    See identical proteins and their annotated locations for XP_006228966.1

    UniProtKB/TrEMBL
    B1WC54
    Related
    ENSRNOP00000020014.4, ENSRNOT00000020014.4
    Conserved Domains (2) summary
    pfam00134
    Location:116243
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:246365
    Cyclin_C; Cyclin, C-terminal domain

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    85114968..85124206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center