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Apoe apolipoprotein E [ Rattus norvegicus (Norway rat) ]

Gene ID: 25728, updated on 4-Dec-2018

Summary

Official Symbol
Apoeprovided by RGD
Official Full Name
apolipoprotein Eprovided by RGD
Primary source
RGD:2138
See related
Ensembl:ENSRNOG00000018454
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
APOEA
Summary
plays a role in plasma lipoprotein transport [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 45248.9), Adrenal (RPKM 6775.4) and 5 other tissues See more
Orthologs

Genomic context

See Apoe in Genome Data Viewer
Location:
1q21
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80612894..80616820, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (81878372..81882298, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene apolipoprotein C4 Neighboring gene apolipoprotein C1 Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene nectin cell adhesion molecule 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amyloid-beta binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT amyloid-beta binding IDA
Inferred from Direct Assay
more info
PubMed 
amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
 
amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
amyloid-beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
antioxidant activity ISO
Inferred from Sequence Orthology
more info
 
cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol transporter activity ISO
Inferred from Sequence Orthology
more info
 
heparan sulfate proteoglycan binding IEA
Inferred from Electronic Annotation
more info
 
heparan sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
heparan sulfate proteoglycan binding ISS
Inferred from Sequence or Structural Similarity
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
hydroxyapatite binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid binding ISO
Inferred from Sequence Orthology
more info
 
lipid transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
lipid transporter activity IEA
Inferred from Electronic Annotation
more info
 
lipid transporter activity ISO
Inferred from Sequence Orthology
more info
 
lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
low-density lipoprotein particle receptor binding IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal chelating activity IEA
Inferred from Electronic Annotation
more info
 
metal chelating activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylcholine-sterol O-acyltransferase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylcholine-sterol O-acyltransferase activator activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylcholine-sterol O-acyltransferase activator activity ISO
Inferred from Sequence Orthology
more info
 
phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
protein dimerization activity ISO
Inferred from Sequence Orthology
more info
 
NOT protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
tau protein binding IEA
Inferred from Electronic Annotation
more info
 
tau protein binding ISO
Inferred from Sequence Orthology
more info
 
very-low-density lipoprotein particle receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very-low-density lipoprotein particle receptor binding IEA
Inferred from Electronic Annotation
more info
 
very-low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
AMPA glutamate receptor clustering IEA
Inferred from Electronic Annotation
more info
 
AMPA glutamate receptor clustering ISO
Inferred from Sequence Orthology
more info
 
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
NMDA glutamate receptor clustering IEA
Inferred from Electronic Annotation
more info
 
NMDA glutamate receptor clustering ISO
Inferred from Sequence Orthology
more info
 
aging IDA
Inferred from Direct Assay
more info
PubMed 
amyloid precursor protein metabolic process IEA
Inferred from Electronic Annotation
more info
 
amyloid precursor protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT axon regeneration ISO
Inferred from Sequence Orthology
more info
 
cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
cardiovascular system development ISO
Inferred from Sequence Orthology
more info
 
cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to cholesterol IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol catabolic process ISO
Inferred from Sequence Orthology
more info
 
cholesterol efflux IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol efflux IEA
Inferred from Electronic Annotation
more info
 
cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
cholesterol efflux ISS
Inferred from Sequence or Structural Similarity
more info
 
cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol homeostasis IEA
Inferred from Electronic Annotation
more info
 
cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
chylomicron remnant clearance IEA
Inferred from Electronic Annotation
more info
 
chylomicron remnant clearance ISO
Inferred from Sequence Orthology
more info
 
chylomicron remnant clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid homeostasis IEA
Inferred from Electronic Annotation
more info
 
fatty acid homeostasis ISO
Inferred from Sequence Orthology
more info
 
high-density lipoprotein particle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
high-density lipoprotein particle assembly IEA
Inferred from Electronic Annotation
more info
 
high-density lipoprotein particle assembly ISO
Inferred from Sequence Orthology
more info
 
high-density lipoprotein particle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
high-density lipoprotein particle clearance IEA
Inferred from Electronic Annotation
more info
 
high-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
high-density lipoprotein particle remodeling IEA
Inferred from Electronic Annotation
more info
 
high-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
intermediate-density lipoprotein particle clearance IEA
Inferred from Electronic Annotation
more info
 
intermediate-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
intermediate-density lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
lipid transport IDA
Inferred from Direct Assay
more info
PubMed 
lipid transport involved in lipid storage ISO
Inferred from Sequence Orthology
more info
 
lipoprotein biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lipoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
lipoprotein biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
lipoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipoprotein catabolic process ISO
Inferred from Sequence Orthology
more info
 
lipoprotein metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipoprotein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
lipoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
locomotory exploration behavior IEA
Inferred from Electronic Annotation
more info
 
locomotory exploration behavior ISO
Inferred from Sequence Orthology
more info
 
long-chain fatty acid transport IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid transport ISO
Inferred from Sequence Orthology
more info
 
long-term memory IEA
Inferred from Electronic Annotation
more info
 
long-term memory ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
maintenance of location in cell ISO
Inferred from Sequence Orthology
more info
 
negative regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of amyloid-beta formation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cholesterol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of platelet activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of presynaptic membrane organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of presynaptic membrane organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
neuron projection development IEA
Inferred from Electronic Annotation
more info
 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
neuron projection regeneration TAS
Traceable Author Statement
more info
PubMed 
nitric oxide mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
oligodendrocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
peripheral nervous system axon regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
phospholipid efflux IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid efflux IEA
Inferred from Electronic Annotation
more info
 
phospholipid efflux ISO
Inferred from Sequence Orthology
more info
 
positive regulation by host of viral process IEA
Inferred from Electronic Annotation
more info
 
positive regulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of axon extension IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cholesterol efflux IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol esterification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cholesterol esterification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cholesterol esterification ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendritic spine development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendritic spine maintenance IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heparan sulfate binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heparan sulfate binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heparan sulfate proteoglycan binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heparan sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipid transport across blood brain barrier IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lipid transport across blood brain barrier ISO
Inferred from Sequence Orthology
more info
 
positive regulation of low-density lipoprotein particle receptor catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of low-density lipoprotein particle receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phospholipid efflux IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phospholipid efflux ISO
Inferred from Sequence Orthology
more info
 
positive regulation of postsynaptic membrane organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of postsynaptic membrane organization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein import IEA
Inferred from Electronic Annotation
more info
 
protein import ISO
Inferred from Sequence Orthology
more info
 
NOT protein localization ISO
Inferred from Sequence Orthology
more info
 
receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of Cdc42 protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of Cdc42 protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
regulation of amyloid fibril formation IEA
Inferred from Electronic Annotation
more info
 
regulation of amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
regulation of amyloid-beta clearance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 
regulation of amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
regulation of behavioral fear response ISO
Inferred from Sequence Orthology
more info
 
regulation of cellular response to very-low-density lipoprotein particle stimulus IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular response to very-low-density lipoprotein particle stimulus ISO
Inferred from Sequence Orthology
more info
 
regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
regulation of plasma lipoprotein particle levels ISO
Inferred from Sequence Orthology
more info
 
regulation of proteasomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of synapse organization ISO
Inferred from Sequence Orthology
more info
 
regulation of triglyceride metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
response to D-galactosamine IEP
Inferred from Expression Pattern
more info
PubMed 
response to caloric restriction IEA
Inferred from Electronic Annotation
more info
 
response to caloric restriction ISO
Inferred from Sequence Orthology
more info
 
response to dietary excess ISO
Inferred from Sequence Orthology
more info
 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
response to zinc ion IEP
Inferred from Expression Pattern
more info
PubMed 
reverse cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
reverse cholesterol transport IEA
Inferred from Electronic Annotation
more info
 
reverse cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
 
triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
 
triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
triglyceride-rich lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
triglyceride-rich lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
vasodilation ISO
Inferred from Sequence Orthology
more info
 
very-low-density lipoprotein particle clearance IEA
Inferred from Electronic Annotation
more info
 
very-low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
very-low-density lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
very-low-density lipoprotein particle remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very-low-density lipoprotein particle remodeling IEA
Inferred from Electronic Annotation
more info
 
very-low-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
virion assembly IEA
Inferred from Electronic Annotation
more info
 
virion assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
chylomicron IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chylomicron IDA
Inferred from Direct Assay
more info
PubMed 
chylomicron IEA
Inferred from Electronic Annotation
more info
 
chylomicron ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
discoidal high-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with early endosome IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
high-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
high-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
intermediate-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intermediate-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
intermediate-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
intermediate-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synaptic cleft IEA
Inferred from Electronic Annotation
more info
 
synaptic cleft ISO
Inferred from Sequence Orthology
more info
 
very-low-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
very-low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
very-low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
apolipoprotein E
Names
apo-E

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270681.1NP_001257610.1  apolipoprotein E precursor

    See identical proteins and their annotated locations for NP_001257610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AABR07002678, BC086581
    UniProtKB/Swiss-Prot
    P02650
    Related
    ENSRNOP00000050968.3, ENSRNOT00000041891.5
    Conserved Domains (3) summary
    pfam01442
    Location:78256
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl03075
    Location:55124
    GrpE; nucleotide exchange factor GrpE
    cl21478
    Location:209291
    ATP-synt_B; ATP synthase B/B' CF(0)
  2. NM_001270682.1NP_001257611.1  apolipoprotein E precursor

    See identical proteins and their annotated locations for NP_001257611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AABR07002678, BC086581
    UniProtKB/Swiss-Prot
    P02650
    Conserved Domains (3) summary
    pfam01442
    Location:78256
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl03075
    Location:55124
    GrpE; nucleotide exchange factor GrpE
    cl21478
    Location:209291
    ATP-synt_B; ATP synthase B/B' CF(0)
  3. NM_001270683.1NP_001257612.1  apolipoprotein E precursor

    See identical proteins and their annotated locations for NP_001257612.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AABR07002678, BC086581
    UniProtKB/Swiss-Prot
    P02650
    Related
    ENSRNOP00000071702.1, ENSRNOT00000080453.1
    Conserved Domains (3) summary
    pfam01442
    Location:78256
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl03075
    Location:55124
    GrpE; nucleotide exchange factor GrpE
    cl21478
    Location:209291
    ATP-synt_B; ATP synthase B/B' CF(0)
  4. NM_001270684.1NP_001257613.1  apolipoprotein E precursor

    See identical proteins and their annotated locations for NP_001257613.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AABR07002678, BC086581
    UniProtKB/Swiss-Prot
    P02650
    Related
    ENSRNOP00000068937.1, ENSRNOT00000091574.1
    Conserved Domains (3) summary
    pfam01442
    Location:78256
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl03075
    Location:55124
    GrpE; nucleotide exchange factor GrpE
    cl21478
    Location:209291
    ATP-synt_B; ATP synthase B/B' CF(0)
  5. NM_138828.3NP_620183.2  apolipoprotein E precursor

    See identical proteins and their annotated locations for NP_620183.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AABR07002678, BC086581
    UniProtKB/Swiss-Prot
    P02650
    Conserved Domains (3) summary
    pfam01442
    Location:78256
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl03075
    Location:55124
    GrpE; nucleotide exchange factor GrpE
    cl21478
    Location:209291
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    80612894..80616820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    73813122..73817046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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